| Size | Price | |
|---|---|---|
| Other Sizes |
| ln Vivo |
According to studies, allyl isopropyl acetamide induces a noticeable green pigmentation in the liver in addition to increasing the amount of porphyrins in animal urine and liver. After receiving high dosages of allylisopropyl acetamide over an extended period of time, the rats showed good recovery and their measured parameters returned to normal. Rats may tolerate and recover from the harm produced by long-term allyl isopropyl acetamide treatment [1]. Aprons have been linked to recorded cases of mucocutaneous ocular syndrome and fixed medication eruptions [2].
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|---|---|
| References | |
| Additional Infomation |
Apronal is a N-acylurea.
Apronalide is approved in Japan. Apronalide has been withdrawn from the market in many other countries due to patient development of thrombocytopenic purpura. |
| Molecular Formula |
C9H16N2O2
|
|---|---|
| Molecular Weight |
184.24
|
| Exact Mass |
184.121
|
| CAS # |
528-92-7
|
| PubChem CID |
10715
|
| Appearance |
White to off-white solid powder
|
| Density |
1.025g/cm3
|
| Melting Point |
196 °C
|
| Index of Refraction |
1.474
|
| LogP |
2.12
|
| Hydrogen Bond Donor Count |
2
|
| Hydrogen Bond Acceptor Count |
2
|
| Rotatable Bond Count |
4
|
| Heavy Atom Count |
13
|
| Complexity |
212
|
| Defined Atom Stereocenter Count |
0
|
| InChi Key |
KSUUMAWCGDNLFK-UHFFFAOYSA-N
|
| InChi Code |
InChI=1S/C9H16N2O2/c1-4-5-7(6(2)3)8(12)11-9(10)13/h4,6-7H,1,5H2,2-3H3,(H3,10,11,12,13)
|
| Chemical Name |
N-carbamoyl-2-propan-2-ylpent-4-enamide
|
| Synonyms |
ApronalApronalideIsodormidSedormidAllylisopropylacetylurea
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
DMSO : ~150 mg/mL (~814.16 mM)
|
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 3.75 mg/mL (20.35 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 37.5 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 5.4277 mL | 27.1385 mL | 54.2770 mL | |
| 5 mM | 1.0855 mL | 5.4277 mL | 10.8554 mL | |
| 10 mM | 0.5428 mL | 2.7139 mL | 5.4277 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
Products are for research use only; We do not sell to patients
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