Size | Price | Stock | Qty |
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500mg |
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1g |
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5g |
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Other Sizes |
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ln Vitro |
Alpha-amino acids include arginine. Among the twenty most prevalent naturally occurring amino acids is the L-form. In terms of molecular genetics, the triplets CGU, CGC, CGA, CGG, AGA, and AGG are nucleotide bases or codons that code for arginine during protein synthesis. These bases are found in the structure of messenger ribonucleic acid (mRNA). Arginine is categorized as either a conditionally essential or semi-essential amino acid in mammals based on the developmental stage and overall health of the individual. In individuals with severe sepsis, L-arginine was linked to a lower cardiac index but no change in stroke index. In 40% of the L-arginine group and 24% of the placebo group, shock subsided in less than 72 hours. After receiving chronic simvastatin therapy (2 mg/kg subcutaneously daily for 14 days), L-arginine (450 mg/kg over 15 min) boosts absolute brain eNOS upregulation and amplifies and maintains hyperemia (38%) in the brain. Blood flow in mice with SV-129.
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References |
[1]. Bakker J, et al. Administration of the nitric oxide synthase inhibitor NG-methyl-L-arginine hydrochloride (546C88) by intravenous infusion for up to 72 hours can promote the resolution of shock in patients with severe sepsis: results of a randomized, double-blind, placebo-controlled multicenter study (study no. 144-002). Crit Care Med. 2004 Jan;32(1):1-12.
[2]. Tapiero H, et al. I. Arginine. Biomed Pharmacother. 2002 Nov;56(9):439-45. [3]. Yamada M, et al. Endothelial nitric oxide synthase-dependent cerebral blood flow augmentation by L-arginine after chronic statin treatment. J Cereb Blood Flow Metab. 2000 Apr;20(4):709-17. |
Molecular Formula |
C6H15CLN4O2
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Molecular Weight |
210.66
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CAS # |
1119-34-2
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Related CAS # |
DL-Arginine;7200-25-1;L-Arginine-15N2 hydrochloride;204633-92-1;L-Arginine-15N4 hydrochloride;204633-95-4;L-Arginine-d7 hydrochloride;204244-77-9;L-Arginine-13C6 hydrochloride;201740-91-2;L-Arginine-13C6,15N4 hydrochloride;202468-25-5;L-Arginine butanoate;80407-72-3;L-Arginine-1-13C hydrochloride;2483735-41-5;L-Arginine-13C6,15N4,d7 hydrochloride;2483829-29-2;L-Arginine-1,2-13C2 hydrochloride;201740-75-2;L-Arginine-13C hydrochloride;94740-43-9;L-Arginine-15N4,d7 hydrochloride
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Appearance |
Typically exists as solids (or liquids in special cases) at room temperature
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SMILES |
Cl[H].O([H])C([C@]([H])(C([H])([H])C([H])([H])C([H])([H])/N=C(\N([H])[H])/N([H])[H])N([H])[H])=O
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Synonyms |
NSC-203450 NSC203450NSC 203450 Arginine HCl Detoxargin LevarginArginine Hydrochloride
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HS Tariff Code |
2934.99.9001
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Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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Solubility (In Vitro) |
H2O : ~100 mg/mL (~474.70 mM)
DMSO :< 1 mg/mL |
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Solubility (In Vivo) |
Solubility in Formulation 1: 100 mg/mL (474.70 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication.
 (Please use freshly prepared in vivo formulations for optimal results.) |
Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
1 mM | 4.7470 mL | 23.7349 mL | 47.4699 mL | |
5 mM | 0.9494 mL | 4.7470 mL | 9.4940 mL | |
10 mM | 0.4747 mL | 2.3735 mL | 4.7470 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration: mg/mL;
Method for preparing DMSO stock solution: mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation::Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.