Age-related myelin damage induces inflammatory responses, yet its involvement in Alzheimer's disease remains uncertain, despite age being a major risk factor. Using a mouse model of Alzheimer's disease, we found that amyloidosis itself triggers age-related oligodendrocyte and myelin damage. Mechanistically, CD8+ T cells promote the progressive accumulation of abnormally interferon-activated microglia that display myelin-damaging activity. Thus, our data suggest that immune responses against myelinating oligodendrocytes may contribute to neurodegenerative diseases with amyloidosis.
Congratulations to Prof. Mikael Simons from University Hospital of Munich (Germany) and co-authors for their wonderful work published in Nat Neurosci (IF=25)!
InvivoChem is proud to provide Professor Mikael Simons with our high-quality product Baricitinib (Cat #: V0338 ; CAS #: 1187594-09-7, JAK1/JAK2 inhibitor) for this research.
References: Nat Neurosci. 2024 Aug;27(8):1468-1474. doi: 10.1038/s41593-024-01682-8.
