News

142022-09

Eprenetapopt triggers ferroptosis, inhibits NFS1 cysteine desulfurase, and synergizes with serine and glycine dietary restriction [Science Adv] by researchers from The University of Melbourne, Monash University (Australia), and Memorial Sloan Kettering Cancer Center (USA)
The mechanism of action of eprenetapopt (APR-246, PRIMA-1MET) as an anticancer agent remains unresolved, although the clinical development of eprenetapopt focuses on its reported mechanism of action as a mutant-p53 reactivator.

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242021-08

A clinically applicable integrative molecular classification of meningiomas [Nature (IF=66)!] by researchers from University of Toronto (Canada), National Cancer Institute (NCI/NIH), University Hospital Tübingen (Germany), and University of California Los Angeles (UCLA)
Meningiomas are the most common primary intracranial tumour in adults1.

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112021-04

MDMX acts as a pervasive preleukemic-to-acute myeloid leukemia transition mechanism [Cancer Cell (IF=50)!] by researchers from Albert Einstein College of Medicine, The University of Texas MD Anderson Cancer Center (USA), and University of Oxford (UK)
MDMX is overexpressed in the vast majority of patients with acute myeloid leukemia (AML).

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252020-11

Neurons Release Serine to Support mRNA Translation in Pancreatic Cancer [Cell (IF=67)!] by researchers from New York University, M.D. Anderson Cancer Center, and Dana-Farber Cancer Institute
Pancreatic ductal adenocarcinoma (PDAC) tumors have a nutrient-poor, desmoplastic, and highly innervated tumor microenvironment.

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012013-12

Basal activity of PINK1 and PRKN in cell models and rodent brain [Autophagy (IF=16.02)] by researchers from Mayo Clinic and University of Alabama at Birmingham
The ubiquitin kinase-ligase pair PINK1-PRKN recognizes and transiently labels damaged mitochondria with ubiquitin phosphorylated at Ser65 (p-S65-Ub) to mediate their selective degradation (mitophagy).

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