| Size | Price | Stock | Qty |
|---|---|---|---|
| 500mg |
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| 1g |
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| Other Sizes |
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| ln Vitro |
The B16F10 cell conditioned medium has a relative molecular mass of less than 5,000 for the active components, and it strongly reduces apoptosis induced by Sodium L-ascorbate (10 mM) [4].
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|---|---|
| ln Vivo |
Compared to Tg rats not treated with sodium L-ascorbate (Sodium L-ascorbate), Tg rats treated with sodium L-ascorbate (15.4%) had a greater incidence of cancer (29.6%). Transgenic rats showed several organ cancers, even in the absence of L-ascorbic acid sodium salt therapy [5]. All animals experienced simple hyperplasia and papillary or nodular (PN) hyperplasia following 12 weeks of PEITC treatment; however, most lesions subsided by 48 weeks, irrespective of the administration of sodium salt (L-ascorbic acid) treatment. By week 48, after 24 weeks of PEITC treatment, the same lesions had progressed to dysplasia and cancer in a few cases; however, the rats' simple hyperplasia and PN hyperplasia were the only conditions in which the treatment with L-ascorbic acid sodium salt showed an enhancement impact. [6].
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| References |
[1]. Hinek A, et al. Sodium L-ascorbate enhances elastic fibers deposition by fibroblasts from normal and pathologic human skin. J Dermatol Sci. 2014 Sep;75(3):173-82.
[2]. Aleksander Hinek, et al. Sodium L-ascorbate enhances elastic fibers deposition by fibroblasts from normal and pathologic human skin. J Dermatol Sci. 2014 Sep;75(3):173-82. [3]. Michael T Nelson, et al. Molecular mechanisms of subtype-specific inhibition of neuronal T-type calcium channels by ascorbate. J Neurosci. 2007 Nov 14;27(46):12577-83. [4]. Yang X, et al. Mouse melanoma cell line B16F10-derived conditioned medium inhibits sodium L-ascorbate-induced B16F10 cell apoptosis. Nan Fang Yi Ke Da Xue Xue Bao. 2012 Feb;32(2):146-50. [5]. Morimura K, et al. Lack of urinary bladder carcinogenicity of sodium L-ascorbate in human c-Ha-ras proto-oncogene transgenic rats. Toxicol Pathol. 2005;33(7):764-7. [6]. Takagi H, et al. Limited tumor-initiating activity of phenylethyl isothiocyanate by promotion with sodium L-ascorbate in a rat two-stage urinary bladder carcinogenesis model. Cancer Lett. 2005 Mar 10;219(2):147-53 |
| Molecular Formula |
C6H7NAO6
|
|---|---|
| Molecular Weight |
198.11
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| CAS # |
134-03-2
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| Related CAS # |
L-Ascorbic acid;50-81-7;L-Ascorbic acid (GMP Like);50-81-7
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| Appearance |
Typically exists as solids (or liquids in special cases) at room temperature
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| SMILES |
[Na+].O1C(C(=C([C@@]1([H])[C@]([H])(C([H])([H])O[H])O[H])[O-])O[H])=O
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| Synonyms |
Ascorbate Vitamin C sodium Sodium Ascorbate
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture and light. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
H2O : ~100 mg/mL (~504.77 mM)
DMSO : ~1 mg/mL (~5.05 mM) |
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: 50 mg/mL (252.39 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication.
(Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 5.0477 mL | 25.2385 mL | 50.4770 mL | |
| 5 mM | 1.0095 mL | 5.0477 mL | 10.0954 mL | |
| 10 mM | 0.5048 mL | 2.5239 mL | 5.0477 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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