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Description: AT406 (also known as SM-406, ARRY-334543) is a novel, potent and orally bioavailable Smac/DIABLO mimetic and an antagonist of IAP (inhibitor of apoptosis protein via E3 ubiquitin ligase). It binds to XIAP-BIR3, cIAP1-BIR3 and cIAP2-BIR3 with Ki of 66.4 nM, 1.9 nM, and 5.1 nM, 50- to 100-fold higher affinities than the Smac AVPI peptide. It has been shown to inhibit cancer cell growth in various human cancer cell lines and to induce apoptosis in xenograft tumors in mice
References: Cancer Res. 2004 Oct 15;64(20):7183-90.
Related CAS:1071992-57-8 (HCl salt)
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2
Purity ≥98%
COA
MSDS