Size | Price | Stock | Qty |
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5mg |
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10mg |
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25mg |
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50mg |
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100mg |
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Other Sizes |
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ln Vitro |
Similar efficaciousness against MDR isolates of M is exhibited by AU1235 in conjunction to fluoroquinolones, ethambutol, and/or streptomycin. resistance to pyrazinamide, rifampicin, and isoniazid in tuberculosis patients. medicinal qualities. Although the minimum inhibitory concentration (MIC) of AU1235 (3.2 to 6.4 μg/ml) is considerably higher than that of Mycobacterium tuberculosis and Mycobacterium bovis BCG, it still inhibits Mycobacterium smegmatis and Mycobacterium fortuitum [2].
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References |
[1]. McNeil MB, et al. Multiple Mutations in Mycobacterium tuberculosis MmpL3 Increase Resistance to MmpL3 Inhibitors. mSphere. 2020;5(5):e00985-20. Published 2020 Oct 14.
[2]. Grzegorzewicz AE, et al. Inhibition of mycolic acid transport across the Mycobacterium tuberculosis plasma membrane. Nat Chem Biol. 2012;8(4):334-341. Published 2012 Feb 19. |
Molecular Formula |
C17H19F3N2O
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Molecular Weight |
324.34
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Exact Mass |
324.1449
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Elemental Analysis |
C, 62.95; H, 5.90; F, 17.57; N, 8.64; O, 4.93
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CAS # |
1338780-86-1
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Related CAS # |
941678-49-5;
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Appearance |
Solid powder
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SMILES |
O=C(NC1=CC=C(F)C(F)=C1F)NC2C3CC4CC(C3)CC2C4
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InChi Key |
FRRHMLGKNPFRKT-UHFFFAOYSA-N
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InChi Code |
InChI=1S/C17H19F3N2O/c18-12-1-2-13(15(20)14(12)19)21-17(23)22-16-10-4-8-3-9(6-10)7-11(16)5-8/h1-2,8-11,16H,3-7H2,(H2,21,22,23)
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Chemical Name |
1-(2-Adamantyl)-3-(2,3,4-trifluorophenyl)urea
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Synonyms |
AU1235; AU-1235; AU 1235
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HS Tariff Code |
2934.99.9001
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Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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Solubility (In Vitro) |
Ethanol : ~65 mg/mL
DMSO : 10~25 mg/mL ( 30.83~77.08 mM) |
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Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (7.71 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C,1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (7.71 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly. Solubility in Formulation 3: 10% DMSO+90% (20% SBE-β-CD in Saline): ≥ 2.5 mg/mL (7.71 mM)  (Please use freshly prepared in vivo formulations for optimal results.) |
Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
1 mM | 3.0832 mL | 15.4159 mL | 30.8318 mL | |
5 mM | 0.6166 mL | 3.0832 mL | 6.1664 mL | |
10 mM | 0.3083 mL | 1.5416 mL | 3.0832 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration: mg/mL;
Method for preparing DMSO stock solution: mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation::Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.