Size | Price | Stock | Qty |
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25mg |
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50mg |
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100mg |
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250mg |
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500mg |
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1g |
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Other Sizes |
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Purity: ≥98%
Azasetron HCl (formerly Y 25130 HCl; Y-25130; Y25130), an approved antiemetic drug, is a potent and selective antagonist of 5-HT3 receptor with an IC50 of 0.33 nM. It is an antiemetic medication that is mainly used to treat nausea and vomiting brought on by cancer chemotherapy.
Targets |
5-HT3 Receptor ( IC50 = 0.33 nM )
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ln Vivo |
Azasetron has the ability to enter the systemic circulation by effectively penetrating the skin[2].
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Animal Protocol |
Four male Bama miniature pigs weighing 9-11 kg (15-16 weeks old)
0.5 mg/kg I.V. administration via the abdominal vein. |
References |
Molecular Formula |
C17H21CL2N3O3
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Molecular Weight |
386.27
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Exact Mass |
385.1
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Elemental Analysis |
C, 52.86; H, 5.48; Cl, 18.35; N, 10.88; O, 12.43
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CAS # |
123040-16-4
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Related CAS # |
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Appearance |
Solid powder
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SMILES |
CN1C(=O)COC2=C(C=C(C=C21)Cl)C(=O)NC3CN4CCC3CC4.Cl
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InChi Key |
DBMKBKPJYAHLQP-UHFFFAOYSA-N
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InChi Code |
InChI=1S/C17H20ClN3O3.ClH/c1-20-14-7-11(18)6-12(16(14)24-9-15(20)22)17(23)19-13-8-21-4-2-10(13)3-5-21;/h6-7,10,13H,2-5,8-9H2,1H3,(H,19,23);1H
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Chemical Name |
N-(1-azabicyclo[2.2.2]octan-3-yl)-6-chloro-4-methyl-3-oxo-1,4-benzoxazine-8-carboxamide;hydrochloride
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Synonyms |
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HS Tariff Code |
2934.99.9001
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Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
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Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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Solubility (In Vitro) |
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Solubility (In Vivo) |
Solubility in Formulation 1: 50 mg/mL (129.44 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication.
 (Please use freshly prepared in vivo formulations for optimal results.) |
Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
1 mM | 2.5889 mL | 12.9443 mL | 25.8886 mL | |
5 mM | 0.5178 mL | 2.5889 mL | 5.1777 mL | |
10 mM | 0.2589 mL | 1.2944 mL | 2.5889 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration: mg/mL;
Method for preparing DMSO stock solution: mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation::Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.