| Size | Price | Stock | Qty |
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| 5mg |
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| 10mg |
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| 25mg |
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| 50mg |
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| 100mg |
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| 250mg |
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Purity: ≥98%
AZD5904 is a novel, potent, orally bioavailable, irreversible inhibitor of human MPO (Myeloperoxidase) with an IC50 of 140 nM and with similar potency in mouse and rat. It is 10 to 19-fold selective compared to the closely related lactoperoxidase and thyroid peroxidase; it shows >70-fold selectivity over a broad panel of other enzymes, ion channels, and receptors. In isolated human neutrophils, 1 μM inhibited PMA stimulated HOCl by >90%. In rats, a plasma concentration of ~5 μM decreased the in vivo formation of glutathione sulphonamide (a product of the reaction of HOCl with glutathione) from in situ zymosan activated peritoneum neutrophils.
| ln Vitro |
The human myeloperoxidase (MPO) enzyme AZD5904 exhibits both irreversible and selective behavior. Its potency remains consistent across many models and topologies, with an IC50 of 140 nM. In addition to being >70 times more selective than a variety of other enzymes, ion channels, and receptors, AZD5904 is 10–19 times more selective than thyroid peroxidases and lactoperoxidases, which are closely related [1].
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| References |
| Molecular Formula |
C10H12N4O2S
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|---|---|
| Molecular Weight |
252.292880058289
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| Exact Mass |
252.068
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| CAS # |
618913-30-7
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| PubChem CID |
10264211
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| Appearance |
White to yellow solid powder
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| Density |
1.5±0.1 g/cm3
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| Index of Refraction |
1.704
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| LogP |
-1.43
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| Hydrogen Bond Donor Count |
2
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| Hydrogen Bond Acceptor Count |
4
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| Rotatable Bond Count |
2
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| Heavy Atom Count |
17
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| Complexity |
351
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| Defined Atom Stereocenter Count |
1
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| SMILES |
C1C[C@@H](OC1)CN2C3=C(C(=O)NC2=S)NC=N3
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| InChi Key |
RSPDBEVKURKEII-ZCFIWIBFSA-N
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| InChi Code |
InChI=1S/C10H12N4O2S/c15-9-7-8(12-5-11-7)14(10(17)13-9)4-6-2-1-3-16-6/h5-6H,1-4H2,(H,11,12)(H,13,15,17)/t6-/m1/s1
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| Chemical Name |
3-[[(2R)-oxolan-2-yl]methyl]-2-sulfanylidene-7H-purin-6-one
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~100 mg/mL (~396.37 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.08 mg/mL (8.24 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.9637 mL | 19.8185 mL | 39.6369 mL | |
| 5 mM | 0.7927 mL | 3.9637 mL | 7.9274 mL | |
| 10 mM | 0.3964 mL | 1.9818 mL | 3.9637 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
Products are for research use only; We do not sell to patients
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