Size | Price | Stock | Qty |
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5mg |
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10mg |
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50mg |
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Other Sizes |
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Azvudine HCl (RO-0622; FNC; RO0622) is a nucleoside reverse transcriptase inhibitor (NRTI) approved in 2021 in China as an anti-HIV drug. It may also be used for the treatment of novel coronavirus pneumonia (COVID-19).
ln Vitro |
Azvudine (RO-0622) hydrochloride, with an EC50 range from 30-110 pM, shows potent inhibitory effects on HIV-1IIIB and HIV-1RF wild-type. Azvudine hydrochloride's EC50 values against HIV-1KM018, HIV-1TC-1, and HIV-1WAN T69N are 6.92, 0.34, and 0.45 nM, in that order. The EC50 value of azvudine hydrochloride is 0.11, 0.14, 0.37, and 0.36 nM for the NRTI-resistant strain HIV-174V, the PIs-resistant strain HIV-1L10R/M46I/L63P/V82T/I84V, the HIV-1RF V82F/184V, and the FIs-resistant strain pNL4-3gp41 (36G) V38A/N42T, respectively.
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References |
[1]. Wang RR, et al. Azvudine, a novel nucleoside reverse transcriptase inhibitor showed good drug combination features and better inhibition on drug-resistant strains than lamivudine in vitro. PLoS One. 2014 Aug 21;9(8):e105617.
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Molecular Formula |
C₉H₁₂CLFN₆O₄
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Molecular Weight |
322.68
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CAS # |
1333126-31-0
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Related CAS # |
Azvudine;1011529-10-4
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Appearance |
Typically exists as solids (or liquids in special cases) at room temperature
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SMILES |
Cl.F[C@@H]1[C@H](N2C(N=C(C=C2)N)=O)O[C@](CO)([C@H]1O)N=[N+]=[N-]
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Synonyms |
Azvudine HClRO-0622FNC RO0622
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HS Tariff Code |
2934.99.9001
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Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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Solubility (In Vitro) |
H2O : ~125 mg/mL (~387.38 mM)
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Solubility (In Vivo) |
Solubility in Formulation 1: 14.29 mg/mL (44.29 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication (<60°C).
 (Please use freshly prepared in vivo formulations for optimal results.) |
Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
1 mM | 3.0990 mL | 15.4952 mL | 30.9905 mL | |
5 mM | 0.6198 mL | 3.0990 mL | 6.1981 mL | |
10 mM | 0.3099 mL | 1.5495 mL | 3.0990 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration: mg/mL;
Method for preparing DMSO stock solution: mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation::Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.