| Size | Price | Stock | Qty |
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| 1mg |
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| 5mg |
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| 10mg |
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| Other Sizes |
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| ln Vitro |
I09 has an IC50 of 1230 nM, making it an inhibitor of IRE-1 RNase[1]. Applying this inhibitor (B I09) to CLL cells causes symptoms similar to XBP-1 deficiency, such as increased IRE-1 expression and disrupted BCR signaling. B I09 has the ability to efficiently block the expression of XBP-1 in LPS-stimulated B cells and the splicing of XBP1 mRNA in human WaC3 cells [2].
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| ln Vivo |
I09 has a half-life of roughly 1.5 hours, and 15 minutes after treatment, mouse plasma reaches peak concentrations of about 39 μM. B I09 administration to mice with CLL tumors prevents the spread of leukemia by triggering apoptosis without harming the body as a whole [2].
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| References |
| Molecular Formula |
C16H17NO5
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|---|---|
| Molecular Weight |
303.309884786606
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| Exact Mass |
303.11
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| CAS # |
1607803-67-7
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| PubChem CID |
86290458
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| Appearance |
Yellow to brown solid powder
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| LogP |
0.3
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| Hydrogen Bond Donor Count |
2
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| Hydrogen Bond Acceptor Count |
6
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| Rotatable Bond Count |
1
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| Heavy Atom Count |
22
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| Complexity |
485
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| Defined Atom Stereocenter Count |
0
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| SMILES |
C1NCCC2C3=CC=C(O)C(C4OCCCO4)=C3OC(=O)C1=2
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| InChi Key |
UYYMWNUDIOPESF-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C16H17NO5/c18-12-3-2-10-9-4-5-17-8-11(9)15(19)22-14(10)13(12)16-20-6-1-7-21-16/h2-3,16-18H,1,4-8H2
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| Chemical Name |
7-(1,3-dioxan-2-yl)-8-hydroxy-1,2,3,4-tetrahydrochromeno[3,4-c]pyridin-5-one
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: (1). This product requires protection from light (avoid light exposure) during transportation and storage. (2). This product is not stable in solution, please use freshly prepared working solution for optimal results. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~8.33 mg/mL (~27.46 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: 2.5 mg/mL (8.24 mM) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), suspension solution; with sonication.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.2970 mL | 16.4848 mL | 32.9696 mL | |
| 5 mM | 0.6594 mL | 3.2970 mL | 6.5939 mL | |
| 10 mM | 0.3297 mL | 1.6485 mL | 3.2970 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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