Size | Price | Stock | Qty |
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10mg |
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25mg |
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50mg |
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100mg |
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250mg |
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Other Sizes |
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Purity: ≥98%
Bavachinin (BVC; 7-O-Methylbavachin; Bavachinin A) is a naturally occuring compound isolated from the fruit of the traditional Chinese herb Fructus Psoraleae (FP). It has potent anti-angiogenic activity.
ln Vivo |
In nude mice, babachinin (5 mg/kg; intraperitoneal injection; seven consecutive days) can impede kit KB tumor growth and angiogenesis [2]. Tumors in mice can be treated with bevacidin (50 mg/kg; intraperitoneal injection; seven consecutive days) [
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Cell Assay |
Immunofluorescence[4]
Cell Types: A549 Cell Tested Concentrations: 25 μM, 50 μM Incubation Duration: 24 h Experimental Results: Shows PPARγ protein levels in the cytoplasm and cytoplasm Bavachinin (25, 50 μM; 24 h) increases PPARγ protein expression[4] . The cell nuclei were Dramatically elevated. |
Animal Protocol |
Animal/Disease Models: Athymic nude mice were inoculated subcutaneously (sc) (sc) with KB cells [2]
Doses: 5 mg/kg Route of Administration: intraperitoneal (ip) injection Experimental Results: It demonstrated that the tumor volume was Dramatically diminished by 40.06%, and the lumen size and blood vessels were less. 3]. Animal/Disease Models: Asthma mice [3] Doses: 50 mg/kg Route of Administration: po (oral gavage) Experimental Results: demonstrated significant inhibition of serum IL-4 and IgE levels. |
References |
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Additional Infomation |
Bavachinin is a member of flavanones.
Bavachinin has been reported in Cullen corylifolium with data available. See also: Cullen corylifolium fruit (part of). |
Molecular Formula |
C21H22O4
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Molecular Weight |
338.3970
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Exact Mass |
338.151
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CAS # |
19879-30-2
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PubChem CID |
10337211
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Appearance |
White to light yellow solid powder
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Density |
1.2±0.1 g/cm3
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Boiling Point |
537.1±50.0 °C at 760 mmHg
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Melting Point |
139-145ºC
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Flash Point |
190.3±23.6 °C
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Vapour Pressure |
0.0±1.5 mmHg at 25°C
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Index of Refraction |
1.590
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LogP |
4.93
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Hydrogen Bond Donor Count |
1
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Hydrogen Bond Acceptor Count |
4
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Rotatable Bond Count |
4
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Heavy Atom Count |
25
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Complexity |
488
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Defined Atom Stereocenter Count |
1
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SMILES |
CC(=CCC1=CC2=C(C=C1OC)O[C@@H](CC2=O)C3=CC=C(C=C3)O)C
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InChi Key |
VOCGSQHKPZSIKB-FQEVSTJZSA-N
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InChi Code |
InChI=1S/C21H22O4/c1-13(2)4-5-15-10-17-18(23)11-20(14-6-8-16(22)9-7-14)25-21(17)12-19(15)24-3/h4,6-10,12,20,22H,5,11H2,1-3H3/t20-/m0/s1
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Chemical Name |
(2S)-2,3-dihydro-2-(4-hydroxyphenyl)-7-methoxy-6-(3-methyl-2-buten-1-yl)-4H-1-benzopyran-4-one
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Synonyms |
7-O-Methylbavachin
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HS Tariff Code |
2934.99.9001
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Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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Solubility (In Vitro) |
DMSO : ~125 mg/mL (~369.39 mM)
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Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.08 mg/mL (6.15 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.08 mg/mL (6.15 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly.  (Please use freshly prepared in vivo formulations for optimal results.) |
Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
1 mM | 2.9551 mL | 14.7754 mL | 29.5508 mL | |
5 mM | 0.5910 mL | 2.9551 mL | 5.9102 mL | |
10 mM | 0.2955 mL | 1.4775 mL | 2.9551 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration: mg/mL;
Method for preparing DMSO stock solution: mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation::Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.