| Size | Price | Stock | Qty |
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| 5mg |
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| 10mg |
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| 25mg |
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| 50mg |
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| 100mg |
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| 250mg |
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Purity: ≥98%
Bavisant dihydrochloride hydrate (also known as JNJ-31001074 dihydrochloride hydrate) is a novel, highly selective, orally bioactive antagonist of the human H3 receptor with a novel mechanism of action which involves wakefulness and cognition. It might be applied as an ADHD treatment. Non-histamine neurons contain histamine H3 receptors, which control other neurotransmitters like acetylcholine and norepinephrine. This suggests that H3 antagonists may be able to reduce impulsivity and enhance attention. According to research, H3 receptor antagonists may have a special therapeutic effect and provide a significant alternative for the treatment of ADHD because of their novel mechanism of action.
| Targets |
H3 receptor
|
|---|---|
| ln Vivo |
Bavisant dihydrochloride hydrate raises the levels of acetylcholine in the rat frontal cortex[4].
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| References |
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| Molecular Formula |
C19H31CL2N3O3
|
|---|---|
| Molecular Weight |
420.37374329567
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| Exact Mass |
419.174
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| Elemental Analysis |
C, 54.29; H, 7.43; Cl, 16.87; N, 10.00; O, 11.42
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| CAS # |
1103522-80-0
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| Related CAS # |
Bavisant; 929622-08-2; Bavisant dihydrochloride; 929622-09-3
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| PubChem CID |
56843503
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| Appearance |
White to pink solid powder
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| LogP |
2.792
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| Hydrogen Bond Donor Count |
3
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| Hydrogen Bond Acceptor Count |
5
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| Rotatable Bond Count |
4
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| Heavy Atom Count |
27
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| Complexity |
418
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| Defined Atom Stereocenter Count |
0
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| SMILES |
O=C(N1CCN(C2CC2)CC1)C(C=C3)=CC=C3CN4CCOCC4.[H]Cl.[H]Cl.O
|
| InChi Key |
BLFBQJUVAGIUBL-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C19H27N3O2.2ClH.H2O/c23-19(22-9-7-21(8-10-22)18-5-6-18)17-3-1-16(2-4-17)15-20-11-13-24-14-12-20;;;/h1-4,18H,5-15H2;2*1H;1H2
|
| Chemical Name |
(4-cyclopropylpiperazin-1-yl)-[4-(morpholin-4-ylmethyl)phenyl]methanone;hydrate;dihydrochloride
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| Synonyms |
Bavisant dihydrochloride hydrate; JNJ-31001074-AAC; JNJ 31001074-AAC; JNJ31001074-AAC
|
| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
H2O: ≥ 50 mg/mL (~118.9 mM)
DMSO: ≥ 1 mg/mL (~2.4 mM) |
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: 50 mg/mL (118.94 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication.
(Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.3789 mL | 11.8943 mL | 23.7886 mL | |
| 5 mM | 0.4758 mL | 2.3789 mL | 4.7577 mL | |
| 10 mM | 0.2379 mL | 1.1894 mL | 2.3789 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
Products are for research use only; We do not sell to patients
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