Size | Price | Stock | Qty |
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50mg |
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100mg |
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250mg |
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500mg |
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1g |
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2g |
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Other Sizes |
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Purity: ≥98%
Benznidazole (Ro-07-1051; NSC-299972; Radanil) is an FDA approved and orally bioavailable antiparasitic drug used in the treatment of Chagas disease. While it is highly effective in early disease this decreases in those who have long term infection. It is the first line treatment given its moderate side effects compared to nifurtimox. On August 29, 2017, the U.S. Food and Drug Administration granted accelerated approval to benznidazole for use in children ages 2 to 12 years old with Chagas disease. It is the first treatment approved in the United States for the treatment of Chagas disease.
Targets |
Trypanosoma
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ln Vivo |
When mice infected with Trypanosoma cruzi Tulahuen strain or SGO-Z12 isolate are treated with benzidazole (100 mg/kg/day, p.o., 30 days), the results include a decrease in electrocardiographic alterations, fewer modifications in the affinity and density of cardiac receptors, and a few isolated areas of fibrosis in the heart[1].
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Animal Protocol |
Animal Model: Mice infected with Trypanosoma cruzi Tulahuen strain or SGO-Z12[1]
Dosage: 100 mg/kg/day Administration: Orally for 30 days Result: reduced the number of changes in the affinity and density of cardiac receptors, reduced the number of isolated cardiac fibrosis regions, and decreased electrocardiographic alterations. |
References |
Molecular Formula |
C12H12N4O3
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Molecular Weight |
260.25
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Exact Mass |
260.09
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Elemental Analysis |
C, 55.38; H, 4.65; N, 21.53; O, 18.44
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CAS # |
22994-85-0
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Related CAS # |
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Appearance |
Solid powder
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SMILES |
O=C(NCC1=CC=CC=C1)CN2C=CN=C2[N+]([O-])=O
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InChi Key |
CULUWZNBISUWAS-UHFFFAOYSA-N
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InChi Code |
InChI=1S/C12H12N4O3/c17-11(14-8-10-4-2-1-3-5-10)9-15-7-6-13-12(15)16(18)19/h1-7H,8-9H2,(H,14,17)
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Chemical Name |
2-Nitro-N-(phenylmethyl)-1H-imidazole-1-acetamide
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Synonyms |
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HS Tariff Code |
2934.99.9001
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Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
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Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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Solubility (In Vitro) |
DMSO : 50~52 mg/mL ( 192.12~199.8 mM )
Ethanol : ~5 mg/mL |
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Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.08 mg/mL (7.99 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.08 mg/mL (7.99 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C,1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.08 mg/mL (7.99 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. Solubility in Formulation 4: 10% DMSO+40% PEG300+5% Tween-80+45% Saline: ≥ 2.08 mg/mL (7.99 mM) |
Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
1 mM | 3.8425 mL | 19.2123 mL | 38.4246 mL | |
5 mM | 0.7685 mL | 3.8425 mL | 7.6849 mL | |
10 mM | 0.3842 mL | 1.9212 mL | 3.8425 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration: mg/mL;
Method for preparing DMSO stock solution: mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation::Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.