Size | Price | Stock | Qty |
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1mg |
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Other Sizes |
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Berotralstat (BCX7353, Orladeyo) is a novel, oral and potent kallikrein inhibitor. As of December 2020, Berotralstat was approved by FDA to prevent attacks of hereditary angioedema (HAE)
References |
: Sohtome Y, Sodeoka M. Development of Chaetocin and S-Adenosylmethionine Analogues as Tools for Studying Protein Methylation. Chem Rec. 2018 Dec;18(12):1660-1671.
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Molecular Formula |
C30H26F4N6O
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Molecular Weight |
562.57
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Exact Mass |
562.2104
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CAS # |
1809010-50-1
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Related CAS # |
Berotralstat dihydrochloride;1809010-52-3
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Appearance |
Typically exists as solids (or liquids in special cases) at room temperature
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SMILES |
FC1C=CC(=CC=1NC(C1=CC(C(F)(F)F)=NN1C1C=CC=C(CN)C=1)=O)[C@@H](C1C=CC=C(C#N)C=1)NCC1CC1
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Chemical Name |
1-[3-(aminomethyl)phenyl]-N-(5-{(R)-(3-
cyanophenyl)[(cyclopropylmethyl)amino]methyl}-2-
fluorophenyl)-3-(trifluoromethyl)-1H-pyrazole-5-
carboxamide
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Synonyms |
ORLADEYO BCX-7353 BCX 7353BCX7353
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HS Tariff Code |
2934.99.9001
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Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture. |
Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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Solubility (In Vitro) |
DMSO : ~100 mg/mL (~177.76 mM)
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Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 8.5 mg/mL (15.11 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 85.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly.  (Please use freshly prepared in vivo formulations for optimal results.) |
Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
1 mM | 1.7776 mL | 8.8878 mL | 17.7756 mL | |
5 mM | 0.3555 mL | 1.7776 mL | 3.5551 mL | |
10 mM | 0.1778 mL | 0.8888 mL | 1.7776 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration: mg/mL;
Method for preparing DMSO stock solution: mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation::Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.