| Size | Price | Stock | Qty |
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| 25mg |
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| 50mg |
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| 100mg |
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| 250mg |
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| 500mg |
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| Other Sizes |
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| ln Vitro |
Bisdemethoxycurcumin (BDMC) is a demethoxy derivative of curcumin, which is a natural substance found in the turmeric root. In a dose-dependent manner, BDMC slows the growth of the SGC 7901 gastric cancer cells. Since BDMC prevents cells from progressing to S phase and finishing the cycle, cell growth is stopped in G1 phase[2].
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| ln Vivo |
Through modulating mitochondria, BDMC may encourage tumor apoptosis. In a xenograft model of gastric adenoadenocarcinoma, BDMC inhibits tumor growth and increases body weight[2].
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| Enzyme Assay |
The cells are grown in a humid environment with 5% CO2 at 37°C. As a positive control, DAC is used to assess the hypomethylation effect of bisdemethoxycurcumin. Before use, stock solutions of curcumin, DMC, BDMC, and DAC (20 mM) in dimethyl sulfoxide (DMSO) are prepared and diluted in sterile-filtered media. In 6-well culture plates, 1×105 cells are seeded. Following a 24-hour culture period, the cells are given a 72-hour treatment with curcumin, DMC, BDMC (0-100 μM) or DAC (20 μM).
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| References |
| Molecular Formula |
C₁₉H₁₆O₄
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|---|---|
| Molecular Weight |
308.33
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| Exact Mass |
308.10485899
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| CAS # |
33171-05-0
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| Related CAS # |
Bisdemethoxycurcumin-d8;2470233-08-8
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| Appearance |
Solid
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| SMILES |
C1=CC(=CC=C1/C=C/C(=O)CC(=O)/C=C/C2=CC=C(C=C2)O)O
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| InChi Key |
PREBVFJICNPEKM-YDWXAUTNSA-N
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| InChi Code |
InChI=1S/C19H16O4/c20-16-7-1-14(2-8-16)5-11-18(22)13-19(23)12-6-15-3-9-17(21)10-4-15/h1-12,20-21H,13H2/b11-5+,12-6+
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| Chemical Name |
(1E,6E)-1,7-bis(4-hydroxyphenyl)hepta-1,6-diene-3,5-dione
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| Synonyms |
Bisdemethoxycurcumin; Curcumin III
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO: ~62 mg/mL (201.1 mM)
Ethanol: ~25 mg/mL (~81.1 mM) |
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| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (8.11 mM) (saturation unknown) in 10% DMSO + 40% PEG300 +5% Tween-80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 + to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.2433 mL | 16.2164 mL | 32.4328 mL | |
| 5 mM | 0.6487 mL | 3.2433 mL | 6.4866 mL | |
| 10 mM | 0.3243 mL | 1.6216 mL | 3.2433 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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