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Purity: ≥98%
Bromodiphenhydramine (Bromazine; trade names: Ambodryl, Ambrodil and others) hydrochloride is the hydrochloride salt form of bromodiphenhydramine, a synthetic ethanolamine with histamine H1 antagonistic and sedative properties. The symptoms of histamine activity on capillaries, bronchial smooth muscle, and gastrointestinal smooth muscle—vasodilation, increased capillary permeability, bronchoconstriction, and spasmodic contraction of gastrointestinal smooth muscle—are prevented by bromodiphenhydramine hydrochloride, which blocks the H1 histamine receptor. Additionally, this medication keeps mucous membranes from itching and hurting due to histamine.
| ln Vitro |
Bromodiphenhydramine hydrochloride (1.5 and 3 μg/g, single) protects mice from a virulent strain of Salmonella typhimurium challenge and also significantly lowers the organism's growth in the protected animals' liver, spleen, and blood when compared to the unprotected controls[2].
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| ln Vivo |
Bromdiphenhydramine hydrochloride (1.5 and 3 μg/g, single dose) protects mice against challenge with a virulent strain of Salmonella typhimurium and also significantly reduces the risk of death in protected animals compared with unprotected animals. Control of the reproduction of this microorganism in the liver, spleen and blood [2].
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| References | |
| Additional Infomation |
Bromodiphenhydramine Hydrochloride is the hydrochloride salt form of bromodiphenhydramine, a synthetic ethanolamine with histamine H1 antagonistic and sedative properties. Bromodiphenhydramine hydrochloride blocks the H1 histamine receptor and prevents the symptoms that are caused by histamine activity on capillaries, bronchial smooth muscle, and gastrointestinal smooth muscle, including vasodilation, increased capillary permeability, bronchoconstriction, and spasmodic contraction of gastrointestinal smooth muscle. This drug also prevents histamine-induced pain and itching of mucous membranes.
See also: Bromodiphenhydramine hydrochloride; zinc acetate (component of) ... View More ... |
| Molecular Formula |
C17H21BRCLNO
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|---|---|
| Molecular Weight |
370.71174
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| Exact Mass |
369.05
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| Elemental Analysis |
C, 55.08; H, 5.71; Br, 21.55; Cl, 9.56; N, 3.78; O, 4.32
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| CAS # |
1808-12-4
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| Related CAS # |
Bromodiphenhydramine; 118-23-0
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| PubChem CID |
519514
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| Appearance |
White to off-white solid powder
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| Boiling Point |
397.3ºC at 760 mmHg
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| Flash Point |
194.1ºC
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| Vapour Pressure |
1.61E-06mmHg at 25°C
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| LogP |
4.918
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| Hydrogen Bond Donor Count |
1
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| Hydrogen Bond Acceptor Count |
2
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| Rotatable Bond Count |
6
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| Heavy Atom Count |
21
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| Complexity |
258
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| Defined Atom Stereocenter Count |
0
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| SMILES |
Cl.CN(CCOC(C1C=CC(Br)=CC=1)C1C=CC=CC=1)C
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| InChi Key |
ZQDJSWUEGOYDGT-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C17H20BrNO.ClH/c1-19(2)12-13-20-17(14-6-4-3-5-7-14)15-8-10-16(18)11-9-15;/h3-11,17H,12-13H2,1-2H3;1H
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| Chemical Name |
2-[(4-bromophenyl)-phenylmethoxy]-N,N-dimethylethanamine;hydrochloride
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| Synonyms |
Bromodiphenhydramine HCl; Bromodiphenhydramine hydrochloride
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| HS Tariff Code |
2934.99.03.00
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
May dissolve in DMSO (in most cases), if not, try other solvents such as H2O, Ethanol, or DMF with a minute amount of products to avoid loss of samples
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| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.6975 mL | 13.4876 mL | 26.9753 mL | |
| 5 mM | 0.5395 mL | 2.6975 mL | 5.3951 mL | |
| 10 mM | 0.2698 mL | 1.3488 mL | 2.6975 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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