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100mg |
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250mg |
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500mg |
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1g |
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2g |
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5g |
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10g |
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Other Sizes |
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Purity: ≥98%
Buspirone HCl (MJ90221, MJ-90221, Buspar, MJ-9022-1, MJ9022 1, MJ9022-1), the hydrochloride salt of Buspirone which is an azapirone anolog, is a potent serotonergic 5HT1A receptor agonist with anti-psychotic effects. Buspirone is a psychotropic anxiolytic that has been approved for use. Generalized anxiety disorder (GAD) is the main condition it is used to treat. Buspirone's pharmacology is unrelated to that of benzodiazepines or barbiturates, unlike most medications used primarily to treat anxiety, so there is no chance of physical dependence or withdrawal symptoms.
Targets |
5-HT1A
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ln Vitro |
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ln Vivo |
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Cell Assay |
Cell Line: Lymphocytes
Concentration: 0, 4, 20, 40, 200 and 400 µg/mL Incubation Time: 6 hours Result: Decreased cell viability in a dose-dependent manner. |
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Animal Protocol |
Male C57BL/6N mice
1 and 5 mg/kg Oral gavage and intraperitoneal injection; for 5 days |
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References |
Molecular Formula |
C21H32CLN5O2
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Molecular Weight |
421.96
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Exact Mass |
421.22
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Elemental Analysis |
C, 59.77; H, 7.64; Cl, 8.40; N, 16.60; O, 7.58
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CAS # |
33386-08-2
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Related CAS # |
Buspirone; 36505-84-7; Buspirone-d8 hydrochloride; 1216761-39-5
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Appearance |
White crystalline powder
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SMILES |
C1CCC2(C1)CC(=O)N(C(=O)C2)CCCCN3CCN(CC3)C4=NC=CC=N4.Cl
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InChi Key |
RICLFGYGYQXUFH-UHFFFAOYSA-N
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InChi Code |
InChI=1S/C21H31N5O2.ClH/c27-18-16-21(6-1-2-7-21)17-19(28)26(18)11-4-3-10-24-12-14-25(15-13-24)20-22-8-5-9-23-20;/h5,8-9H,1-4,6-7,10-17H2;1H
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Chemical Name |
8-[4-(4-pyrimidin-2-ylpiperazin-1-yl)butyl]-8-azaspiro[4.5]decane-7,9-dione;hydrochloride
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Synonyms |
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HS Tariff Code |
2934.99.9001
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Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
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Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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Solubility (In Vitro) |
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Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (5.92 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (5.92 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C,1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.5 mg/mL (5.92 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. Solubility in Formulation 4: 15% Captisol, pH 9: 10 mg/mL Solubility in Formulation 5: 100 mg/mL (236.99 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with ultrasonication. |
Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
1 mM | 2.3699 mL | 11.8495 mL | 23.6989 mL | |
5 mM | 0.4740 mL | 2.3699 mL | 4.7398 mL | |
10 mM | 0.2370 mL | 1.1849 mL | 2.3699 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration: mg/mL;
Method for preparing DMSO stock solution: mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation::Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
NCT Number | Recruitment | interventions | Conditions | Sponsor/Collaborators | Start Date | Phases |
NCT01850355 | Active Recruiting |
Drug: Buspirone | Anxiety Autism Spectrum Disorders |
Massachusetts General Hospital | July 2013 | Not Applicable |
NCT02313194 | Active Recruiting |
Device: Epidural Stimulation Drug: Buspirone |
Tetraparesis Tetraplegia Cervical Spinal Cord Injury |
University of California, Los Angeles |
July 2013 | Phase 1 Phase 2 |
NCT05041322 | Recruiting | Drug: Buspirone Drug: Placebo |
Spinal Cord Injuries | Spaulding Rehabilitation Hospital | November 29, 2020 | Phase 2 |
NCT01821690 | Recruiting | Drug: Buspirone Drug: Placebo |
Traumatic Brain Injury | Indiana University | May 2013 | Not Applicable |
NCT05511909 | Recruiting | Drug: Buspirone Drug: Lofexidine Drug: Placebo |
Opioid Use Disorder Opioid Withdrawal Opioid Craving Anxiety |
Johns Hopkins University | December 15, 2022 | Phase 2 |
Buspirone effects on bottom dwelling (sec/min) in zebrafish (mean ± sem). Pharmacol Biochem Behav . 2009 Nov;94(1):75-80. td> |
Buspirone effects on swimming activity (log cm/min) in zebrafish (mean ± sem). Pharmacol Biochem Behav . 2009 Nov;94(1):75-80. td> |