| Size | Price | Stock | Qty |
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| 10mg |
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| 25mg |
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| 50mg |
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| 100mg |
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| 250mg |
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| 500mg |
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| 1g |
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| Other Sizes |
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| ln Vitro |
CCG-100602 is a particular antagonist of the signaling pathway associated with myocardin-related transcription factor A/serum response factor (MRTF-A/SRF). By preventing MRTF-A from nuclear localization, it suppresses the fibrogenic transcription factor SRF.[2]
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| ln Vivo |
CCG-100602 reduces arterial compliance and strain in spontaneously hypertensive rats, which reverses the increase in aortic stiffness. This suggests a strong anti-stiffening effect brought on by the inhibition of SRF/myocardin.[3]
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| Cell Assay |
After 7 days of culture in either basic culture medium (BM), osteogenic medium (OM), or adipogenic medium (AM) supplemented with 15, 20, 25, or 30 μM CCG-1423 or 3, 8, 15, or 30 μM CCG-100602 inhibitor, hASCs are subjected to A/D analysis. While a very small percentage of dead cells are stained with red dye, green dye indicates living cells.
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| Animal Protocol |
Adult (4 month-old) male spontaneously hypertensive rats (SHR) and normotensive control Wistar-Kyoto (WKY) rats
7.5 mg/kg/day osmotic minipumps |
| References |
| Molecular Formula |
C21H17CLF6N2O2
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|---|---|
| Molecular Weight |
478.82
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| Exact Mass |
478.088
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| Elemental Analysis |
C, 52.68; H, 3.58; Cl, 7.40; F, 23.81; N, 5.85; O, 6.68
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| CAS # |
1207113-88-9
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| Related CAS # |
1207113-88-9
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| PubChem CID |
46190808
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| Appearance |
White to off-white solid powder
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| Density |
1.4±0.1 g/cm3
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| Boiling Point |
563.8±50.0 °C at 760 mmHg
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| Flash Point |
294.8±30.1 °C
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| Vapour Pressure |
0.0±1.5 mmHg at 25°C
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| Index of Refraction |
1.544
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| LogP |
5.2
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| Hydrogen Bond Donor Count |
1
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| Hydrogen Bond Acceptor Count |
8
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| Rotatable Bond Count |
3
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| Heavy Atom Count |
32
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| Complexity |
656
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| Defined Atom Stereocenter Count |
0
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| SMILES |
ClC1C=CC(=CC=1)N(C(C1C=C(C(F)(F)F)C=C(C(F)(F)F)C=1)=O)C(C1CNCCC1)=O
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| InChi Key |
MOQCFMZWVKQBAP-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C21H17ClF6N2O2/c22-16-3-5-17(6-4-16)29-18(31)12-2-1-7-30(11-12)19(32)13-8-14(20(23,24)25)10-15(9-13)21(26,27)28/h3-6,8-10,12H,1-2,7,11H2,(H,29,31)
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| Chemical Name |
1-[3,5-bis(trifluoromethyl)benzoyl]-N-(4-chlorophenyl)piperidine-3-carboxamide
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| Synonyms |
CCG100602; CCG 100602; CCG-100602
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: This product requires protection from light (avoid light exposure) during transportation and storage. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO: ~100 mg/mL (~208.9 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 0.83 mg/mL (1.73 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 8.3 mg/mL clear DMSO stock solution to 400 μL of PEG300 and mix evenly; then add 50 μL of Tween-80 to the above solution and mix evenly; then add 450 μL of normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 0.83 mg/mL (1.73 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 8.3 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.0885 mL | 10.4423 mL | 20.8847 mL | |
| 5 mM | 0.4177 mL | 2.0885 mL | 4.1769 mL | |
| 10 mM | 0.2088 mL | 1.0442 mL | 2.0885 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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