| Size | Price | Stock | Qty |
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| 5mg |
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LG-100754 (CD-3159; UVI-2112) is a novel and potent retinoic acid receptors antagonist & agonist or RXR dimers modulater. Specifically, it acts as a RXR:RXR homodimer antagonist, but functions as a agonist towards RXR:PPARα and RXR:PPARγ heterodimers. LG100754 is an insulin sensitizer that functions through RXR.
| ln Vitro |
One specific activator of endogenous RXR heterodimers is LG100754 [1]. In mature adipocytes, TNFα-mediated insulin resistance can also be ameliorated by LG100754 [1]. Genuine activation of the endogenous RXR:PPARγ heterodimer and modulation of insulin-dependent signaling pathways are exhibited by LG100754 [1].
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| ln Vivo |
The fact that LG100754 (100 mg/kg) totally prevents the rise in glucose levels suggests that LG100754 can help the body become more insulin resistant [1].
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| References |
| Molecular Formula |
C26H36O3
|
|---|---|
| Molecular Weight |
396.57
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| Exact Mass |
396.266
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| CAS # |
180713-37-5
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| PubChem CID |
6442223
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| Appearance |
White to off-white solid powder
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| Density |
1.003g/cm3
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| Boiling Point |
549.4ºC at 760 mmHg
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| Flash Point |
178.5ºC
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| Vapour Pressure |
6.63E-13mmHg at 25°C
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| Index of Refraction |
1.526
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| LogP |
6.814
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| Hydrogen Bond Donor Count |
1
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| Hydrogen Bond Acceptor Count |
3
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| Rotatable Bond Count |
7
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| Heavy Atom Count |
29
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| Complexity |
665
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| Defined Atom Stereocenter Count |
0
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| SMILES |
CCCOC1=CC2=C(C=C1/C(=C\C=C\C(=C\C(=O)O)\C)/C)C(CCC2(C)C)(C)C
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| InChi Key |
HNODNXQAYXJFMQ-LQUSFLDPSA-N
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| InChi Code |
InChI=1S/C26H36O3/c1-8-14-29-23-17-22-21(25(4,5)12-13-26(22,6)7)16-20(23)19(3)11-9-10-18(2)15-24(27)28/h9-11,15-17H,8,12-14H2,1-7H3,(H,27,28)/b10-9+,18-15+,19-11-
|
| Chemical Name |
(2E,4E,6Z)-3-methyl-7-(5,5,8,8-tetramethyl-3-propoxy-6,7-dihydronaphthalen-2-yl)octa-2,4,6-trienoic acid
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| Synonyms |
LG100754 UVI2112 CD3159 LG-100754 CD-3159 UVI-2112 CD-3159 CD 3159
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~100 mg/mL (~252.17 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: 2.5 mg/mL (6.30 mM) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.5216 mL | 12.6081 mL | 25.2162 mL | |
| 5 mM | 0.5043 mL | 2.5216 mL | 5.0432 mL | |
| 10 mM | 0.2522 mL | 1.2608 mL | 2.5216 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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