| Size | Price | Stock | Qty |
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| 5mg |
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| 10mg |
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| 50mg |
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| 100mg |
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| Other Sizes |
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| ln Vitro |
Cefditoren (sodium) exhibits good action against Moraxella catarrhalis, Haemophilus influenzae, Haemophilus parainfluenzae, Staphylococcus aureus, and Streptococcus pneumoniae [1]. Microorganism MIC50 (mg/L) MIC90 (mg/L) Susceptible (%) Gram-positive bacteria Streptococcus pneumoniae (untyped)a 0.015-0.25 0.12-1 PS ≤0.008-0.03 0.015-0.25 99-100 PI 0.06-0.5 0.25- 0.5 94-100 PR 0.25-1 0.5-2 7-100 Streptococcus pyogenes ≤0.008-0.03 0.015-0.03 100 Staphylococcus aureus (MS) 0.12-0.5 0.5-1 50-100 Gram Negative bacteria Haemophilus ≤0.008-≤0.03 0.01 5 -0.13 influenza bacilli (untyped)b β-lactamase+ ≤0.008-0.03 0.015-0.06 100 β-lactamase- ≤0.008-0.03 0.015-0.06 100 Haemophilus parainfluenzae ≤0.03 0.06 Moraxella 0.03-0.5 0.25-1 96 Catarrhalis (untyped)b β-lactamase+ ≤0.03-0.25 0.12-0.5 100 β-lactamase- ≤0.008 -0.03 0.015-0.06 100 an Includes PS, PI and PR strains. b Contains both positive and negative strains of β-lactamase. MIC50/90 is the average minimum inhibitory concentration needed to stop the development of 50% or 90% of strains; MS stands for methicillin susceptibility, PI for moderate penicillin sensitivity, PR for penicillin resistance, and PS for penicillin susceptibility.
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| ln Vivo |
Mouse pharmacokinetics [1]:Tlast (h) 6.25 53.0 0.9 30.4 6 12.5 168.4 1.1 64.1 8 25 232.5 0.9 101.3 8 50 290.6 1.1 124.4 8 Cefditoren (mg/kg) C0 (μg/ml) t1/2 (h) AUClast (μg× h/ml)
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| References |
[1]. Wellington K, et al. Cefditoren pivoxil: a review of its use in the treatment of bacterial infections. Drugs. 2004;64(22):2597-618.
[2]. Cafini F, et al. Enhanced in vivo activity of cefditoren in pre-immunized mice against penicillin-resistant S. pneumoniae (serotypes 6B, 19F and 23F) in a sepsis model. PLoS One. 2010 Aug 10;5(8):e12041. |
| Molecular Formula |
C19H18N6O5S3.NA
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|---|---|
| Molecular Weight |
529.56822
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| CAS # |
104146-53-4
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| Related CAS # |
Cefditoren (Pivoxil);117467-28-4;Cefditoren-13C,d3
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| Appearance |
Typically exists as solids (or liquids in special cases) at room temperature
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| SMILES |
[NaH].CO/N=C(\C(NC1C(=O)N2C(=C(CSC12)/C=C/C1SC=NC=1C)C(=O)O)=O)/C1=CSC(N)=N1
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
H2O : ~100 mg/mL (~189.19 mM)
DMSO : ~31.25 mg/mL (~59.12 mM) |
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| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (4.73 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (4.73 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.8883 mL | 9.4416 mL | 18.8832 mL | |
| 5 mM | 0.3777 mL | 1.8883 mL | 3.7766 mL | |
| 10 mM | 0.1888 mL | 0.9442 mL | 1.8883 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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