Size | Price | Stock | Qty |
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25g |
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50g |
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100g |
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200g |
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Other Sizes |
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Purity: ≥98%
Cellulose carboxymethyl ether sodium (cellulose gum; Tylose; Viscosity: 5000-15000 mPa.s) ) is a viscous agent, paste and barrier agent. It is a cellulose derivative with carboxymethyl groups bound to some of the hydroxyl groups of the glucopyranose monomers that make up the cellulose backbone. It is often used as its sodium salt, sodium carboxymethyl cellulose.
ln Vivo |
Preparation of 0.5% CMC-Na Solution
Measure 0.5g dry CMC-Na and dissolve it in 100 ml ddH2O or Saline (0.9 g NaCl in 100 ml ddH2O) to obtain a clear solution. Note 1). Make sure that there is no solid-liquid separation in the CMC-Na solution. The solution is clear without particles in it. 2). Complete dissolution of CMC-Na may take 4 hours or longer. 3). According to literature reports, CMC-Na (oral;5% in water; 1 year) is well tolerated in rats[2]. 4). The LD50 of CMC-Na in female mice is 14 g/kg body weight of mice, equivalent to 9.8 g/kg body weight of rat, and thus is categorized as practically non-toxic according to Loomis criteria (LD50 5-15g/kg body weight of rat)[3]. |
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References |
[1]. Du XH, et al. Dexamethasone and sodium carboxymethyl cellulose prevent postoperative intraperitoneal adhesions in rats. Braz J Med Biol Res. 2015 Apr;48(4):344-8.
[2]. Common Vehicles for Nonclinical Evaluation of Therapeutic Agents. https://onlinelibrary.wiley.com/doi/pdf/10.1002/9780470464151.app5 [3]. Ida Musfiroh, et al. Toxicity Evaluation of Na-CMC synthesized from Cellulose of Water Hyacinth (Eichhornia crassipes (Mart.) Solms).ISSN: 0975-8585 |
Molecular Formula |
[C6H7O2(OH)2OCH2COONA]N
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Molecular Weight |
263.1976
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Elemental Analysis |
C, 36.51; H, 6.13; Na, 8.73; O, 48.63
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CAS # |
9004-32-4
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Related CAS # |
Sodium carboxymethyl cellulose (Viscosity:800-1200 mPa.s);9004-32-4;Sodium carboxymethyl cellulose (Viscosity:5000-15000 mPa.s);9004-32-4;Sodium carboxymethyl cellulose (MW 250000);9004-32-4
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Appearance |
White to off-white solid
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LogP |
158.350
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SMILES |
[Na].O([H])C([H])(C([H])(C([H])([H])O[H])O[H])C([H])(C([H])(C([H])=O)O[H])O[H].O([H])C(C([H])([H])[H])=O |^1:0|
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InChi Key |
DPXJVFZANSGRMM-UHFFFAOYSA-N
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InChi Code |
InChI=1S/C6H12O6.C2H4O2.Na/c7-1-3(9)5(11)6(12)4(10)2-8;1-2(3)4;/h1,3-6,8-12H,2H2;1H3,(H,3,4)
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Chemical Name |
cetic acid compound with 2,3,4,5,6-pentahydroxyhexanal (1:1), sodium
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Synonyms |
Cellulose carboxymethyl ether sodium; Sodium CMC; CMC Na; Carboxymethylcellulose sodium, Sodium carboxymethyl cellulose, Carboxymethyl cellulose sodium; Cellulose gum sodium, CMC salt, CMC sodium
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HS Tariff Code |
2934.99.9001
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Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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Solubility (In Vitro) |
DMSO : ~12.5 mg/mL
H2O : ~8.33 mg/mL |
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Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
1 mM | 3.7994 mL | 18.9970 mL | 37.9939 mL | |
5 mM | 0.7599 mL | 3.7994 mL | 7.5988 mL | |
10 mM | 0.3799 mL | 1.8997 mL | 3.7994 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration: mg/mL;
Method for preparing DMSO stock solution: mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation::Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.