Size | Price | Stock | Qty |
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100mg |
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250mg |
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500mg |
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1g |
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2g |
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5g |
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Other Sizes |
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Purity: ≥98%
Chlorprothixene (Paxyl; Rentovet; Truxal; Ro 4-0403; N-714; MK-184; Taractan; Tarasan), an typical antipsychotic drug of the thioxanthene class, is an antagonist of dopamine and histamine receptors with potential antipsychotic, sedative and antiemetic activity. It inhibits the following dopamine receptors: D1, D2, D3, D5, histamine receptors H1, 5-HT2, and serotonin receptors 5-HT6/7 with Ki values of 18 nM, 2.96 nM, 4.56 nM, 9 nM, 3.75 nM, 9.4 nM, 3 nM and 5.6 nM, respectively.
Targets |
Human D1 Receptor ( Ki = 18 nM ); Human D2 Receptor ( Ki = 2.96 nM ); Human D3 Receptor ( Ki = 4.56 nM ); Human D5 Receptor ( Ki = 9 nM ); Human H1 Receptor ( Ki = 3.75 nM )
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ln Vitro |
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ln Vivo |
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Animal Protocol |
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References |
Molecular Formula |
C18H18CLNS
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Molecular Weight |
315.86
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Exact Mass |
315.08
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Elemental Analysis |
C, 68.45; H, 5.74; Cl, 11.22; N, 4.43; S, 10.15
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CAS # |
113-59-7
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Related CAS # |
Chlorprothixene hydrochloride; 6469-93-8
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Appearance |
Solid powder
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SMILES |
CN(C)CC/C=C\1/C2=CC=CC=C2SC3=C1C=C(C=C3)Cl
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InChi Key |
WSPOMRSOLSGNFJ-AUWJEWJLSA-N
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InChi Code |
InChI=1S/C18H18ClNS/c1-20(2)11-5-7-14-15-6-3-4-8-17(15)21-18-10-9-13(19)12-16(14)18/h3-4,6-10,12H,5,11H2,1-2H3/b14-7-
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Chemical Name |
(3Z)-3-(2-chlorothioxanthen-9-ylidene)-N,N-dimethylpropan-1-amine;hydrochloride
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Synonyms |
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HS Tariff Code |
2934.99.03.00
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Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
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Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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Solubility (In Vitro) |
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Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (7.91 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (7.91 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly.  (Please use freshly prepared in vivo formulations for optimal results.) |
Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
1 mM | 3.1660 mL | 15.8298 mL | 31.6596 mL | |
5 mM | 0.6332 mL | 3.1660 mL | 6.3319 mL | |
10 mM | 0.3166 mL | 1.5830 mL | 3.1660 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration: mg/mL;
Method for preparing DMSO stock solution: mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation::Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
NCT Number | Recruitment | interventions | Conditions | Sponsor/Collaborators | Start Date | Phases |
NCT03449485 | Recruiting | Drug: Chlorprothixene | Obesity, Morbid | Norwegian University of Science and Technology |
January 2, 2018 | N/A |