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ln Vitro |
The compound chyrsin, which is mostly present in gum, honey, and passionflower, has the potential to be used as a preventative and therapeutic tool since it reduces the growth of many types of malignancies in humans. Chrysin exhibits anticancer properties in a range of cancer types; nevertheless, its exact function in ovarian cancer remains unclear, despite the fact that it accumulates poorly and functions as an adjuvant to chemotherapy in conjunction with conventional treatment drugs. In ES2 and OV90 cells, chrysin increases reactive oxygen species (ROS), produces cytoplasmic Ca2+ levels, and induces mitochondrial membrane potential (MMP) to activate MAPK and PI3K/AKT dyes. Chrysin alters the nuclear factor NF-κB signal amplifier cascade dyes and canonical Wnt signal. When compared to untreated control cells, chyrosin induced the phosphorylation of AKT and P70S6K proteins in ES2 and OV90 cells. Furthermore, JNK, p38, and ERK1/2 proteins are phosphorylated by Chrysin epidermal activation medications [1].
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References |
[1]. Lim W, et al. Chrysin Attenuates Progression of Ovarian Cancer Cells by Regulating Signaling Cascades and Mitochondrial Dysfunction. J Cell Physiol. 2017 Aug 17
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Molecular Formula |
C15H10O4
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Molecular Weight |
254.24
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Exact Mass |
254.05791
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Elemental Analysis |
C, 70.86; H, 3.96; O, 25.17
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CAS # |
480-40-0
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Related CAS # |
480-40-0
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Appearance |
Solid powder
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SMILES |
C1=CC=C(C=C1)C2=CC(=O)C3=C(C=C(C=C3O2)O)O
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InChi Key |
RTIXKCRFFJGDFG-UHFFFAOYSA-N
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InChi Code |
InChI=1S/C15H10O4/c16-10-6-11(17)15-12(18)8-13(19-14(15)7-10)9-4-2-1-3-5-9/h1-8,16-17H
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Chemical Name |
5,7-dihydroxy-2-phenylchromen-4-one
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Synonyms |
Galangin flavanone; 57Dihydroxyflavone; NP005901; NP-005901; NP 005901
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HS Tariff Code |
2934.99.9001
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Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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Solubility (In Vitro) |
DMSO: ~51 mg/mL (~200.6 mM)
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Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (9.83 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (9.83 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly.  (Please use freshly prepared in vivo formulations for optimal results.) |
Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
1 mM | 3.9333 mL | 19.6665 mL | 39.3329 mL | |
5 mM | 0.7867 mL | 3.9333 mL | 7.8666 mL | |
10 mM | 0.3933 mL | 1.9666 mL | 3.9333 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration: mg/mL;
Method for preparing DMSO stock solution: mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation::Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.