| Size | Price | |
|---|---|---|
| Other Sizes |
| ln Vitro |
When compared to the control group, lithium citrate tetrahydrate exhibited HIF inhibitory effects in ARPE19 and 661W cells. In ARPE19 cells and 661W cells, lithium citrate tetrahydrate can down-regulate Hif1a and its downstream genes. The treatment of CoCl2 to ARPE19 and 661W cells can lead to enhanced HIF-1α protein expression, which can be inhibited by lithium citrate tetrahydrate [2]. Lithium citrate tetrahydrate decreases lipid droplet accumulation and speeds up energy metabolism in chicken hepatocytes. Lithium citrate tetrahydrate boosts mitochondrial activity and antioxidant status to shield cells against endoplasmic reticulum stress [2].
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|---|---|
| ln Vivo |
Treatment with 100–200 mg/kg of lithium citrate tetrahydrate lowers serum creatinine and blood urea nitrogen, two indicators of renal damage. When lithium citrate tetrahydrate was administered to male C57BL/6J mice, the amount of calcium oxalate crystal formation was considerably decreased. The oxidative stress brought on by calcium oxalate crystals is lessened by lithium citrate tetrahydrate. MCP-1, IL-1β, and IL-6 are examples of inflammatory cytokines that are stimulated by calcium oxalate and are inhibited by lithium citrate tetrahydrate. Furthermore, calcium oxalate crystal-induced renal tubular damage and apoptosis can be lessened by lithium citrate tetrahydrate [1]. Giving animals lithium citrate tetrahydrate can prevent them from gaining weight or accumulating fat [3].
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| References |
[1]. Liu X, et al. Hydroxycitric acid inhibits renal calcium oxalate deposition by reducing oxidative stress and inflammation. Curr Mol Med. 2020 Jan 3.
[2]. Ibuki M, et al. Therapeutic Effect of Garcinia cambogia Extract and Hydroxycitric Acid Inhibiting Hypoxia-Inducible Factor in a Murine Model of Age-Related Macular Degeneration. Int J Mol Sci. 2019 Oct 11;20(20). pii: E5049. [3]. Han S, et al. Hydroxycitric Acid Tripotassium Inhibits Calcium Oxalate Crystal Formation in the Drosophila Melanogaster Model of Hyperoxaluria. Med Sci Monit. 2019 May 17;25:3662-3667. [4]. Heymsfield SB, et al. Garcinia cambogia (hydroxycitric acid) as a potential antiobesity agent: a randomized controlled trial. JAMA. 1998 Nov 11;280(18):1596-600. |
| Molecular Formula |
C6H13LI3O11
|
|---|---|
| Molecular Weight |
281.9838
|
| CAS # |
6080-58-6
|
| Related CAS # |
Sodium citrate dihydrate;6132-04-3;Citric acid;77-92-9;Hydroxycitric acid tripotassium hydrate;6100-05-6;Lithium citrate;919-16-4
|
| Appearance |
Typically exists as solids (or liquids in special cases) at room temperature
|
| SMILES |
O([H])C(C(=O)[O-])(C([H])([H])C(=O)[O-])C([H])([H])C(=O)[O-].O([H])[H].O([H])[H].O([H])[H].O([H])[H].[Li+].[Li+].[Li+]
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
H2O : ≥ 100 mg/mL (~354.64 mM)
|
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: 50 mg/mL (177.32 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication.
(Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.5464 mL | 17.7318 mL | 35.4635 mL | |
| 5 mM | 0.7093 mL | 3.5464 mL | 7.0927 mL | |
| 10 mM | 0.3546 mL | 1.7732 mL | 3.5464 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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