| Size | Price | Stock | Qty |
|---|---|---|---|
| 1mg |
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| 5mg |
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| 10mg |
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| Other Sizes |
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| ln Vitro |
When compared to mock-transfected cells, cjoc42 (0.5, 1 and 5 μM; 48 hours) dose-dependently restores p53 levels and prevents gankyrin-induced p53 level drop in cells [1]. In terms of cell viability, cjoc42 alone (0.1, 1 and 10 μM; 24 hours) did not exhibit any dose-dependent alterations [1].
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|---|---|
| Cell Assay |
Western Blot Analysis[1]
Cell Types: U2OS Tested Concentrations: 0.5, 1 and 5 μM Incubation Duration: 48 hrs (hours) Experimental Results: Dose-dependent restoration of p53 levels (compared to mock-transfected cells) and inhibition of gankyrin-induced decrease in p53 levels in cells . |
| References |
| Molecular Formula |
C20H21N3O5S
|
|---|---|
| Molecular Weight |
415.46
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| Exact Mass |
415.12
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| CAS # |
2171519-89-2
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| Appearance |
Off-white to light yellow solid powder
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| LogP |
3.2
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| SMILES |
C(OC)(=O)C1=CC=C(N2C=C(CCCOS(C3=CC=C(C)C=C3)(=O)=O)N=N2)C=C1
|
| InChi Key |
VYUDJPGSULLWAS-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C20H21N3O5S/c1-15-5-11-19(12-6-15)29(25,26)28-13-3-4-17-14-23(22-21-17)18-9-7-16(8-10-18)20(24)27-2/h5-12,14H,3-4,13H2,1-2H3
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| Chemical Name |
methyl 4-[4-[3-(4-methylphenyl)sulfonyloxypropyl]triazol-1-yl]benzoate
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: This product requires protection from light (avoid light exposure) during transportation and storage. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~100 mg/mL (~240.70 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (6.02 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.4070 mL | 12.0349 mL | 24.0697 mL | |
| 5 mM | 0.4814 mL | 2.4070 mL | 4.8139 mL | |
| 10 mM | 0.2407 mL | 1.2035 mL | 2.4070 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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