| Size | Price | Stock | Qty |
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| 25mg |
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| 50mg |
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| 100mg |
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| 250mg |
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| Other Sizes |
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Clozapine N-oxide diHCl is a major metabolite of Clozapine which is an antipsychotic acting as an antagonist of dopamine and other receptors such as muscarinic M1 receptor.
| Targets |
mAChR4; mAChR3
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|---|---|
| ln Vitro |
Zapine N-oxide (CNO) can be combined with non-DREADD absorption at the concentrations required for DREADD activation and undergo chloride reversal to decrypt the parent compound chloride, an atypical antipsychotic that acts on many pharmacological targets and produce a variety of physiological and behavioral effects [2].
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| ln Vivo |
Clozapine N-oxide dihydrochloride (CNO) network levels at 15 min after a single intraperitoneal (ip) injection of clozapine N-oxide dihydrochloride (1 mg/kg) into mice Highest, very low after 2 hours. Axial half-life in mice is quiescent, but biological effects have been described after rapid handling of experimental animals expressing DREADD, often over long periods of time (6-10 hours) [1].
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| References |
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| Molecular Formula |
C18H21CL3N4O
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|---|---|
| Molecular Weight |
415.7445
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| Exact Mass |
414.08
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| CAS # |
2250025-93-3
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| Related CAS # |
Clozapine N-oxide; 34233-69-7
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| PubChem CID |
137187247
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| Appearance |
Light yellow to yellow solid
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| Hydrogen Bond Donor Count |
3
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| Hydrogen Bond Acceptor Count |
3
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| Rotatable Bond Count |
1
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| Heavy Atom Count |
26
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| Complexity |
491
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| Defined Atom Stereocenter Count |
0
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| InChi Key |
MBRGKRXDVKTUPT-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C18H19ClN4O.2ClH/c1-23(24)10-8-22(9-11-23)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18;;/h2-7,12,20H,8-11H2,1H3;2*1H
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| Chemical Name |
3-chloro-6-(4-methyl-4-oxidopiperazin-4-ium-1-yl)-11H-benzo[b][1,4]benzodiazepine;dihydrochloride
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| Synonyms |
Clozapine Noxide diHCl; Clozapine N oxide diHCl; Clozapine N-oxide dihydrochloride
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO: ~240 mg/mL (~577.3 mM)
H2O: ~100 mg/mL (~240.5 mM) |
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 6 mg/mL (14.43 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 60.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 6 mg/mL (14.43 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 60.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.4053 mL | 12.0267 mL | 24.0535 mL | |
| 5 mM | 0.4811 mL | 2.4053 mL | 4.8107 mL | |
| 10 mM | 0.2405 mL | 1.2027 mL | 2.4053 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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