| Size | Price | Stock | Qty |
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| 5mg |
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| 25mg |
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| 50mg |
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| 100mg |
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Purity: =99.94%
Corilagin, a ellagitannin/gallotannin, is a natural product extracted from Caesalpinia coriaria (Jacq.) Willd. It can also be found in Alchornea glandulosa and in the leaves of Punica granatum. It is a weak carbonic anhydrase inhibitor. Corilagin inhibits activity of reverse transcriptase of RNA tumor viruses. Corilagin inhibits the growth of Staphylococcus aureus with a MIC of 25 μg/mL. Corilagin shows good anti-tumor activity on hepatocellular carcinoma and ovarian cancer. Corilagin shows a low level of toxicity toward normal cells and tissues.
| ln Vitro |
SGC7901 and BGC823 cell growth is inhibited by corilagin (0-50 μM, 24 h), causing the cells to round[2].
Corilagin (0-30 μM, 24 h) induces apoptosis in BGC823 and SGC7901 cells[2]. In SGC7901 and BGC823 cells, corilagin (0-30 μM, 24 h) increased cleaved PARP and decreased the protein levels of procaspase-8, -9, and -3[2]. In SGC7901 and BGC823 cells, corilagin (0-30 μM, 24 h) induces autophagy (enhancement of acidic vesicles, increased level of LC3II)[2]. In SGC7901 and BGC823 cells, corilagin (0-30 μM, 24 h) induces ROS generation[2]. Hey and SKOv3ip cells undergo apoptosis and G2 cell cycle arrest when exposed to corilagin (40 μM) for 24 or 48 hours[3]. Hey, SKOv3ip, and HO8910PM cell secretion of TGF-β1 is inhibited by corilagin (0-80 μM, 1-3 days)[3]. |
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| ln Vivo |
In Hep3B hepatocellular carcinoma, corilagin (15 mg/kg, i.p., for 7 days) exhibits anti-tumor activity[4].
Mice exposed to APAP are protected against hepatotoxicity by corilagin (0–20 mg/kg, i.p.)[5]. |
| Cell Assay |
Cell Line: SGC7901 and BGC823 cell
Concentration: 0, 10, 20, 30, 40 and 50 µM Incubation Time: 24 h Result: exhibited a concentration-dependent inhibition of cell proliferation. |
| Animal Protocol |
Animal Model: Hep3B mouse model for hepatocellular carcinoma[4].
Dosage: 15 mg/kg
Administration: Intraperitoneal injection (i.p.)
Result: Inhibited tumor growth without toxic effects.
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| References |
| Molecular Formula |
C27H22O18
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|---|---|
| Molecular Weight |
634.4528
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| Exact Mass |
634.08
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| Elemental Analysis |
C, 51.11; H, 3.50; O, 45.39
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| CAS # |
23094-69-1
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| Appearance |
Typically exists as solids (or liquids in special cases) at room temperature
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| SMILES |
O=C(OCC1C(C(C(C(O1)OC(C2=CC(O)=C(C(O)=C2)O)=O)O)O3)O)C4=CC(O)=C(C(O)=C4C5=C(C(O)=C(C=C5C3=O)O)O)O
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| InChi Key |
TUSDEZXZIZRFGC-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C27H22O18/c28-9-1-6(2-10(29)16(9)32)24(39)45-27-22(38)23-19(35)13(43-27)5-42-25(40)7-3-11(30)17(33)20(36)14(7)15-8(26(41)44-23)4-12(31)18(34)21(15)37/h1-4,13,19,22-23,27-38H,5H2
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| Chemical Name |
14,15,16,24,25,26,53,55-octahydroxy-3,8-dioxo-53,54,55,56-tetrahydro-52H-4,7-dioxa-5(4,2)-pyrana-1,2(1,2)-dibenzenacyclooctaphane-56-yl 3,4,5-trihydroxybenzoate
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~100 mg/mL (~157.62 mM)
H2O : ~5 mg/mL (~7.88 mM) |
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| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.08 mg/mL (3.28 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.08 mg/mL (3.28 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.08 mg/mL (3.28 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. Solubility in Formulation 4: 5.88 mg/mL (9.27 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with ultrasonication (<60°C). |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.5762 mL | 7.8808 mL | 15.7617 mL | |
| 5 mM | 0.3152 mL | 1.5762 mL | 3.1523 mL | |
| 10 mM | 0.1576 mL | 0.7881 mL | 1.5762 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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