| Size | Price | Stock | Qty |
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| 50mL |
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| 100mL |
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| 250mL |
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| 500mL |
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| 1000mL |
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| Other Sizes |
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Purity: ≥98%
Corn oil is extracted from the germ of corn, and can be used as a co-solvent for solubilizing lipophilic drug molecules for in vivo animal experiments (e.g. Intraperitoneal injections).
| ln Vivo |
Tumors gavaged with maize oil showed a 54% reduction in growth hormone (GH) levels, and osmotic minipump infusion took the place of GH. In animals that were gavaged with water, there was an increase in in situ MNCL cell proliferation. arrival percentage [1]. Corn oil is frequently employed as a feed additive or as a vehicle for the administration of lipophilic drugs in animal research settings [3]. After intraperitoneal injection, tainted corn oil can turn fatal many days later. It is more advisable to provide corn oil intragastrically [4]. Applying maize oil intraperitoneally results in localized inflammation and peritoneal macrophage depletion [5]. Dosing strategy: four intraperitoneal injections spaced seven days apart, one every 48 hours. Findings: Compared to non-pharmaceutical grade corn oil, pharmaceutical grade (PG) corn oil exhibited considerably greater pathology scores on day 21. There were no other notable distinctions between the groups that used corn oil. It is thought to be safe to inject non-pharmaceutical grade maize oil intraperitoneally into mice as it did not have any negative clinical effects.
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| References |
| Molecular Weight |
0
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|---|---|
| CAS # |
8001-30-7
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| Appearance |
Colorless to light yellow liquid
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| Density |
0.900 g/mL at 20 °C
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| Flash Point |
254 °C
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| Index of Refraction |
1.473-1.476
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| SMILES |
BrC1C=C2C=C(C(=O)O)NC2=CN=1
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
Ethanol :≥ 100 mg/mL
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| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
Products are for research use only; We do not sell to patients
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