| Size | Price | Stock | Qty |
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| 5mg |
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| 10mg |
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| 50mg |
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CUDA is a novel and potent inhibitor of sEH (soluble epoxide hydrolase) with potential to be used in cardiovascular disease. It inhibits sEH with IC50s of 11.1 nM and 112 nM for mouse sEH and human sEH, respectively. CUDA selectively increases peroxisome proliferator-activated receptor (PPAR) alpha activity
| Targets |
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|---|---|---|
| ln Vitro |
In COS-7 cells, CUDA (10 μM; 18 hours) stimulates PPARalpha by 6 and 3 times, respectively[2]. In addition to competitively inhibiting Wy-14643 (pirinixic acid) from binding to the PPARalpha ligand binding domain, CUDA does not change the expression of the PPARalpha protein, indicating that it is a PPARalpha ligand[2].
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| Cell Assay |
Western Blot Analysis[2]
Cell Types: COS-7 cells Tested Concentrations: 10 μM Incubation Duration: 18 hrs (hours) Experimental Results: Activated PPARα by binding to the ligand binding domain of PPARα. |
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| References |
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| Additional Infomation |
12-[(Cyclohexylcarbamoyl)amino]dodecanoic acid is a medium-chain fatty acid.
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| Molecular Formula |
C19H36N2O3
|
|---|---|
| Molecular Weight |
340.500745773315
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| Exact Mass |
340.272
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| CAS # |
479413-68-8
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| PubChem CID |
22978774
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| Appearance |
White to off-white solid powder
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| Density |
1.0±0.1 g/cm3
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| Boiling Point |
549.4±19.0 °C at 760 mmHg
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| Flash Point |
286.1±21.5 °C
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| Vapour Pressure |
0.0±3.2 mmHg at 25°C
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| Index of Refraction |
1.501
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| LogP |
4.79
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| Hydrogen Bond Donor Count |
3
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| Hydrogen Bond Acceptor Count |
3
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| Rotatable Bond Count |
13
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| Heavy Atom Count |
24
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| Complexity |
342
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| Defined Atom Stereocenter Count |
0
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| InChi Key |
HPTJABJPZMULFH-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C19H36N2O3/c22-18(23)15-11-6-4-2-1-3-5-7-12-16-20-19(24)21-17-13-9-8-10-14-17/h17H,1-16H2,(H,22,23)(H2,20,21,24)
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| Chemical Name |
12-(cyclohexylcarbamoylamino)dodecanoic acid
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~25 mg/mL (~73.42 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 0.5 mg/mL (1.47 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 5.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.9369 mL | 14.6843 mL | 29.3686 mL | |
| 5 mM | 0.5874 mL | 2.9369 mL | 5.8737 mL | |
| 10 mM | 0.2937 mL | 1.4684 mL | 2.9369 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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