| Size | Price | Stock | Qty |
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| 10mg |
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| 25mg |
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| 50mg |
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| 100mg |
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| 250mg |
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| Other Sizes |
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Cyamemazine (Tercian; Cianatil; cyamepromazine) is a typical antipsychotic drug of the phenothiazine class. It has been utilized to lessen the symptoms of ethanol withdrawal and as an anxiolytic antipsychotic.
| Targets |
5-HT2A Receptor ( Ki = 1.5 nM ); 5-HT2C Receptor ( Ki = 12 nM ); 5-HT3 Receptor ( Ki = 75 nM )
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|---|---|
| ln Vitro |
Cyamemazine's antipsychotic action is consistent with its high affinity for dopamine receptors. Cyamemazine's affinity for M1 (Ki = 13 nM), M2 (Ki = 42 nM), M3 (Ki = 321 nM), M4 (Ki = 12 nM), and M5 (Ki = 35 nM) receptors is consistent with its antagonist activity at muscarinic receptors[1].
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| ln Vivo |
Cyamemazine functions as an antagonist at the 5-HT3, 5-HT2C, and 5-HT2A receptors in the rat brain membrane in the 5-HT2C-dependent phospholipase C stimulation, in the 5-HT3-dependent contraction of the isolated guinea pig ileum and bradycardic responses, and in the 5-HT2A-dependent contraction of the isolated rat aorta rings and the isolated guinea pig trachea. The antagonism of 5-HT3 and 5-HT2C receptors by cyamemazine is partly responsible for its therapeutic action against anxiety disorders. Low doses of cyclomazine administered acutely can lower metabolite and extracellular dopamine concentrations in the rat striatum[1].
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| References |
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| Additional Infomation |
Cyamemazine is a member of phenothiazines.
Cyamemazine (Tercian), also known as cyamepromazine, is a typical antipsychotic drug of the phenothiazine class used primarily in the treatment of schizophrenia and psychosis-associated anxiety. Cyamemazine actually behaves like an atypical antipsychotic, due to its potent anxiolytic effects (5-HT2C) and lack of extrapyramidal side effects (5-HT2A). |
| Molecular Formula |
C19H21N3S
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|---|---|
| Molecular Weight |
323.45
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| Exact Mass |
323.145
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| Elemental Analysis |
C, 70.55; H, 6.54; N, 12.99; S, 9.91
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| CAS # |
3546-03-0
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| Related CAS # |
Cyamemazine-d6; 1216608-24-0
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| PubChem CID |
62865
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| Appearance |
Solid powder
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| Density |
1.2±0.1 g/cm3
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| Boiling Point |
479.0±45.0 °C at 760 mmHg
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| Melting Point |
204-205
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| Flash Point |
243.5±28.7 °C
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| Vapour Pressure |
0.0±1.2 mmHg at 25°C
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| Index of Refraction |
1.655
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| LogP |
4.62
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| Hydrogen Bond Donor Count |
0
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| Hydrogen Bond Acceptor Count |
4
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| Rotatable Bond Count |
4
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| Heavy Atom Count |
23
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| Complexity |
443
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| Defined Atom Stereocenter Count |
0
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| SMILES |
CC(CN(C)C)CN1C2=CC=CC=C2SC3=C1C=C(C=C3)C#N
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| InChi Key |
SLFGIOIONGJGRT-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C19H21N3S/c1-14(12-21(2)3)13-22-16-6-4-5-7-18(16)23-19-9-8-15(11-20)10-17(19)22/h4-10,14H,12-13H2,1-3H3
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| Chemical Name |
10-[3-(dimethylamino)-2-methylpropyl]phenothiazine-2-carbonitrile
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| Synonyms |
Cyamepromazine; TercianCianatil; Cyamemazine
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO: ~100 mg/mL (~309.2 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (7.73 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: 2.5 mg/mL (7.73 mM) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), suspension solution; with ultrasonication. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.5 mg/mL (7.73 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.0917 mL | 15.4583 mL | 30.9167 mL | |
| 5 mM | 0.6183 mL | 3.0917 mL | 6.1833 mL | |
| 10 mM | 0.3092 mL | 1.5458 mL | 3.0917 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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