| Size | Price | |
|---|---|---|
| 100mg | ||
| 500mg |
| ln Vitro |
In neonatal rats, D-alanine causes dose-dependent depolarization of motor neurons [2].
|
|---|---|
| ln Vivo |
Mice's prepulse inhibition deficit caused by dizozepine (0.1 mg/kg) is alleviated when D-alanine (100 mg/kg, oral) is coupled with CBIO (30 mg/kg) [3].
|
| References |
|
| Additional Infomation |
D-alanine is the D-enantiomer of alanine. It has a role as a human metabolite, an EC 4.3.1.15 (diaminopropionate ammonia-lyase) inhibitor and an Escherichia coli metabolite. It is a D-alpha-amino acid and an alanine. It is a conjugate base of a D-alaninium. It is a conjugate acid of a D-alaninate. It is an enantiomer of a L-alanine. It is a tautomer of a D-alanine zwitterion.
The D-enantiomer of alanine. D-Alanine is a metabolite found in or produced by Escherichia coli (strain K12, MG1655). D-alanine has been reported in Euphorbia prostrata, Pinus densiflora, and other organisms with data available. A non-essential amino acid that occurs in high levels in its free state in plasma. It is produced from pyruvate by transamination. It is involved in sugar and acid metabolism, increases IMMUNITY, and provides energy for muscle tissue, BRAIN, and the CENTRAL NERVOUS SYSTEM. See also: Alanine (annotation moved to). |
| Molecular Formula |
C3H7NO2
|
|---|---|
| Molecular Weight |
89.0932
|
| Exact Mass |
89.047
|
| CAS # |
338-69-2
|
| Related CAS # |
26701-36-0
|
| PubChem CID |
71080
|
| Appearance |
White to off-white solid powder
|
| Density |
1.2±0.1 g/cm3
|
| Boiling Point |
212.9±23.0 °C at 760 mmHg
|
| Melting Point |
278-282ºC
|
| Flash Point |
82.6±22.6 °C
|
| Vapour Pressure |
0.1±0.9 mmHg at 25°C
|
| Index of Refraction |
1.460
|
| LogP |
-0.68
|
| Hydrogen Bond Donor Count |
2
|
| Hydrogen Bond Acceptor Count |
3
|
| Rotatable Bond Count |
1
|
| Heavy Atom Count |
6
|
| Complexity |
61.8
|
| Defined Atom Stereocenter Count |
1
|
| SMILES |
C[C@H](C(=O)O)N
|
| InChi Key |
QNAYBMKLOCPYGJ-UWTATZPHSA-N
|
| InChi Code |
InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m1/s1
|
| Chemical Name |
(2R)-2-aminopropanoic acid
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
H2O : ~120 mg/mL (~1346.95 mM)
DMSO :< 1 mg/mL |
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: 50 mg/mL (561.23 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication.
(Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 11.2246 mL | 56.1230 mL | 112.2460 mL | |
| 5 mM | 2.2449 mL | 11.2246 mL | 22.4492 mL | |
| 10 mM | 1.1225 mL | 5.6123 mL | 11.2246 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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