Size | Price | Stock | Qty |
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5mg |
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10mg |
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25mg |
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50mg |
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100mg |
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250mg |
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500mg |
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Other Sizes |
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Purity: ≥98%
Delamanid (formerly also known as OPC-67683; Deltyba) is a new neneration and potent drug that acts as a mycobacterial cell wall synthesis inhibitor for the treatment of multi-drug-resistant tuberculosis. It inhibits the synthesisi of mucolic acids, cruciala component of the cell wall of the Mycobacterium tuberculosis complex. Delamanid was approved in the EU. Delamanid is insoluble in water and its activity was proven in several in vitro and in vivo studies. Its bactericidal activity was demonstrated in individuals with drug-susceptible and drug-resistant tuberculosis (MDR- and XDR-TB).
ln Vitro |
Mycobacterium tuberculosis complex's cell wall is made up primarily of mucolic acids, which are inhibited by delamanid[1].
When it comes to M. tuberculosis strains that are both drug-susceptible and drug-resistant, delamanid exhibits more potent antibacterial activity[2]. The coadministration of delamanid results in approximately 25% higher ethambutol AUCτ and Cmax values; however, delamanid does not affect the exposure to pyrazinamide, rifampin, or isoniazid[3]. |
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ln Vivo |
In a mouse model of VL, delamanid (oral administration; 30 mg/kg; 5 days) causes sterile cures[4].
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References |
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Molecular Formula |
C25H25F3N4O6
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Molecular Weight |
534.4844
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Exact Mass |
534.17
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Elemental Analysis |
C, 56.18; H, 4.71; F, 10.66; N, 10.48; O, 17.96
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CAS # |
681492-22-8
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Related CAS # |
Delamanid-d4
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Appearance |
Solid powder
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SMILES |
FC(F)(F)OC1=CC=C(OC2CCN(C3=CC=C(OC[C@@]4(C)CN5C(O4)=NC([N+]([O-])=O)=C5)C=C3)CC2)C=C1
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InChi Key |
XDAOLTSRNUSPPH-XMMPIXPASA-N
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InChi Code |
InChI=1S/C25H25F3N4O6/c1-24(15-31-14-22(32(33)34)29-23(31)38-24)16-35-18-4-2-17(3-5-18)30-12-10-20(11-13-30)36-19-6-8-21(9-7-19)37-25(26,27)28/h2-9,14,20H,10-13,15-16H2,1H3/t24-/m1/s1
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Chemical Name |
(2R)-2-Methyl-6-nitro-2-[(4-{4-[4-(trifluoromethoxy)phenoxy]-1-piperidinyl}phenoxy)methyl]-2,3-dihydroimidazo[2,1-b][1,3]oxazole
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Synonyms |
OPC-67683; OPC 67683; OPC67683; trade name Deltyba
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HS Tariff Code |
2934.99.9001
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Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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Solubility (In Vitro) |
DMSO : ~100 mg/mL ( ~187.09 mM)
Ethanol : ~2 mg/mL (~3.74 mM) |
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Solubility (In Vivo) |
Solubility in Formulation 1: 2.5 mg/mL (4.68 mM) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), suspension solution; with sonication.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.08 mg/mL (3.89 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly. View More
Solubility in Formulation 3: 10% DMSO+40% PEG300+5% Tween-80+45% Saline: 2.5 mg/mL (4.68 mM) |
Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
1 mM | 1.8710 mL | 9.3549 mL | 18.7098 mL | |
5 mM | 0.3742 mL | 1.8710 mL | 3.7420 mL | |
10 mM | 0.1871 mL | 0.9355 mL | 1.8710 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration: mg/mL;
Method for preparing DMSO stock solution: mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation::Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.