Size | Price | Stock | Qty |
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5mg |
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10mg |
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25mg |
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50mg |
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100mg |
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250mg |
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Other Sizes |
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ln Vitro |
Deoxypodophyllotoxin (25-75 nM; 6-48 hours) increases, for 24 and 48 hours, the proportion of early apoptotic cell population from 2.05 to 5.62 and 18.49%, respectively[1].
Deoxypodophyllotoxin (25-75 nM; 6-48 hours) treats G2/M-arrested SGC-7901 cells in a time- and dose-dependent manner[1].
Deoxypodophyllotoxin (25–75 nM; 6-48 hours) significantly reduces the expression levels of Cdc2 and Cdc25C in a time- and dose-dependent manner, increases cyclin B1 within 6 hours, and lowers the activity of PARP, Bcl-2, and caspase-3[1].
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ln Vivo |
Deoxypodophyllotoxin (intravenously injected; 5, 10, and 20 mg/kg; 3 times a week; 28 days) suppresses tumors in a dose-dependent manner; at 5, 10, and 20 mg/kg, DPT inhibits tumor growth by 22.19%, 47.91%, and 50.93%, respectively[1].
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Animal Protocol |
Xenograft model of gastric cancer in nude mice with SGC-7901 cells[1]
5, 10, and 20 mg/kg Intravenously injected; 5, 10, and 20 mg/kg; 3 times a week; 28 days |
References |
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Molecular Formula |
C22H22O7
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Molecular Weight |
398.4059
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Exact Mass |
398.14
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Elemental Analysis |
C, 66.32; H, 5.57; O, 28.11
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CAS # |
19186-35-7
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Related CAS # |
19186-35-7
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Appearance |
Solid powder
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SMILES |
COC1=CC(=CC(=C1OC)OC)[C@H]2[C@@H]3[C@@H](CC4=CC5=C(C=C24)OCO5)COC3=O
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InChi Key |
ZGLXUQQMLLIKAN-SVIJTADQSA-N
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InChi Code |
InChI=1S/C22H22O7/c1-24-17-6-12(7-18(25-2)21(17)26-3)19-14-8-16-15(28-10-29-16)5-11(14)4-13-9-27-22(23)20(13)19/h5-8,13,19-20H,4,9-10H2,1-3H3/t13-,19+,20-/m0/s1
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Chemical Name |
(5R,5aR,8aR)-5-(3,4,5-trimethoxyphenyl)-5a,8,8a,9-tetrahydro-5H-[2]benzofuro[5,6-f][1,3]benzodioxol-6-one
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Synonyms |
Deoxypodophyllotoxin; Anthricin; AS2-3; AS 2-3; AS-2-3
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HS Tariff Code |
2934.99.9001
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Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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Solubility (In Vitro) |
DMSO: ~80 mg/mL (~200.8 mM)
Ethanol: ~10 mg/mL (~25.1 mM) |
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Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (6.27 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (6.27 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C,1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.5 mg/mL (6.27 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
1 mM | 2.5100 mL | 12.5499 mL | 25.0998 mL | |
5 mM | 0.5020 mL | 2.5100 mL | 5.0200 mL | |
10 mM | 0.2510 mL | 1.2550 mL | 2.5100 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration: mg/mL;
Method for preparing DMSO stock solution: mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation::Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
Antiproliferative activity of deoxypodophyllotoxin (DPT). Molecules . 2015 Jan 20;20(1):1661-75. td> |