Size | Price | Stock | Qty |
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5mg |
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10mg |
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50mg |
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100mg |
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500mg |
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Other Sizes |
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ln Vitro |
The inhibition of CYP2D6 by desvenlafaxine succinate hydrate may lead to higher amounts of medications metabolized by this route. Additionally, desvenlafaxine succinate hydrate stimulates CYP3A4, which may have an impact on how medications that this enzyme metabolizes are metabolized [2].
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ln Vivo |
Desvenlafaxine succinate hydrate (30 mg/kg, orally) dramatically raised extracellular NE levels using microdialysis, but had little effect on DA levels [1].
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Animal Protocol |
Animal/Disease Models: Male rat [1].
Doses: 30 mg/kg. Mode of Route of Administration: Orally. Experimental Results: Using microdialysis, extracellular NE levels in the hypothalamus of male rats Dramatically increased compared with baseline, but had no effect on DA levels. |
References |
[1]. Darlene C Deecher, et al. Desvenlafaxine succinate: A new serotonin and norepinephrine reuptake inhibitor. J Pharmacol Exp Ther. 2006 Aug;318(2):657-65.
[2]. Michael A Sopko Jr, et al. Desvenlafaxine: another "me too" drug? Ann Pharmacother. 2008 Oct;42(10):1439-46. |
Molecular Formula |
C20H33NO7
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Molecular Weight |
399.2257
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Exact Mass |
399.2257
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CAS # |
386750-22-7
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Related CAS # |
Desvenlafaxine;93413-62-8;Desvenlafaxine succinate;448904-47-0;Desvenlafaxine fumarate;93414-04-1;Desvenlafaxine hydrochloride;300827-87-6
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Appearance |
Typically exists as solids (or liquids in special cases) at room temperature
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SMILES |
O=C(O)CCC(O)=O.OC1=CC=C(C(C2(O)CCCCC2)CN(C)C)C=C1.[H]O[H]
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Chemical Name |
4-(2-(dimethylamino)-1-(1-hydroxycyclohexyl)ethyl)phenol succinate hydrate
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Synonyms |
Desvenlafaxine Succinate hydrate;DVS 233;DVS233;DVS-233 WY-45233;WY 45233;WY45233;Pristiq
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HS Tariff Code |
2934.99.9001
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Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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Solubility (In Vitro) |
DMSO : ≥ 33 mg/mL (~82.61 mM)
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Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.08 mg/mL (5.21 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.08 mg/mL (5.21 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C,1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.08 mg/mL (5.21 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
1 mM | 2.5048 mL | 12.5241 mL | 25.0482 mL | |
5 mM | 0.5010 mL | 2.5048 mL | 5.0096 mL | |
10 mM | 0.2505 mL | 1.2524 mL | 2.5048 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration: mg/mL;
Method for preparing DMSO stock solution: mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation::Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.