Devimistat (CPI-613)

Alias: CPI613; CPI-613; Devimistat; CPI 613
Cat No.:V0853 Purity: ≥98%
Devimistat (formerly also known as CPI613; CPI 613; CPI-613), a synthetic lipoate analog, is a novel and potent inhibitor ofpyruvate dehydrogenase (PDH)andα-ketoglutarate dehydrogenase with potential chemopreventive and antineoplastic activities.
Devimistat (CPI-613) Chemical Structure CAS No.: 95809-78-2
Product category: Dehydrogenase
This product is for research use only, not for human use. We do not sell to patients.
Size Price Stock Qty
5mg
25mg
50mg
100mg
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1g
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Other Forms of Devimistat (CPI-613):

  • Devimistat-d10 (CPI-613-d10)
Official Supplier of:
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Top Publications Citing lnvivochem Products
InvivoChem's Devimistat (CPI-613) has been cited by 1 publication
Purity & Quality Control Documentation

Purity: ≥98%

Purity: ≥98%

Product Description

Devimistat (formerly also known as CPI613; CPI 613; CPI-613), a synthetic lipoate analog, is a novel and potent inhibitor of pyruvate dehydrogenase (PDH) and α-ketoglutarate dehydrogenase with potential chemopreventive and antineoplastic activities. It disrupts mitochondrial metabolism and shows strong antitumor activity. Devimistat inhibits mitochondrial enzymes pyruvate dehydrogenase (PDH) and α-ketoglutarate dehydrogenase in NCI-H460 cell line, it disrupts tumor cell mitochondrial metabolism. CPI-613 is developed to target the pyruvate dehydrogenase complex which is a key mitochondrial enzyme of anaerobic glycolysis in tumor cells.

Biological Activity I Assay Protocols (From Reference)
ln Vitro
GPM-2 stomach cancer cells undergo apoptosis when exposed to devimistat. Devimistat specifically targets a modified version of mitochondrial energy metabolism that tumor cells use. Devimistat causes alterations in the cellular redox state and mitochondrial enzyme activity, which result in cell death, including apoptosis [1].
ln Vivo
CPI-613 (25 mg/kg) has potent anticancer activity in a human tumor xenograft model of of a pancreatic tumor cell (BxPC-3). Similarly, CPI-613 (10 mg/kg) also produces significant tumor growth inhibition of H460 human non-small cell lung carcinoma in mouse model. Besides, CPI-613 produces little or no side-effect toxicity in expected therapeutic dose ranges in large animal models and has the maximum tolerated dose of 100 mg/kg in mice.
Animal Protocol
Dissolved in DMSO and then diluted in water.; 25 mg/kg; i.p. administration
CD1 nu/nu mice bearing BxPC-3 and H460 cells tumor models
References
[1]. Sakuratani T, et al. Downregulation of ARID1A in gastric cancer cells: a putative protective molecular mechanism against the Harakiri-mediated apoptosis pathway. Virchows Arch. 2021;478(3):401-411.
These protocols are for reference only. InvivoChem does not independently validate these methods.
Physicochemical Properties
Molecular Formula
C22H28O2S2
Molecular Weight
388.59
CAS #
95809-78-2
SMILES
O=C(O)CCCCC(SCC1=CC=CC=C1)CCSCC2=CC=CC=C2
Chemical Name
6,8-bis(benzylthio)octanoic acid
Synonyms
CPI613; CPI-613; Devimistat; CPI 613
Storage

Powder      -20°C    3 years

                     4°C     2 years

In solvent   -80°C    6 months

                  -20°C    1 month

Shipping Condition
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
Solubility Data
Solubility (In Vitro)
DMSO: 78 mg/mL (200.7 mM)
Water:<1 mg/mL
Ethanol:78 mg/mL (200.7 mM)
Solubility (In Vivo)
1% DMSO+30% polyethylene glycol+1% Tween 80:30 mg/mL
 (Please use freshly prepared in vivo formulations for optimal results.)
Preparing Stock Solutions 1 mg 5 mg 10 mg
1 mM 2.5734 mL 12.8670 mL 25.7341 mL
5 mM 0.5147 mL 2.5734 mL 5.1468 mL
10 mM 0.2573 mL 1.2867 mL 2.5734 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.

Calculator

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Note: Chemical formula is case sensitive: C12H18N3O4  c12h18n3o4
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In vivo Formulation Calculator (Clear solution)
Step 1: Enter information below (Recommended: An additional animal to make allowance for loss during the experiment)
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Calculation results

Working concentration mg/mL;

Method for preparing DMSO stock solution mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation:Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
             (2) Be sure to add the solvent(s) in order.

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