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Dianemycin (Nanchangmycin) is a potent antiviral agent with a broad spectrum antiviral active against Zika virus. It is a polyether, polyalcohol, monocarboxylic acid isolated from Streptomyces hygroscopicus which binds metal monovalent cations.
Targets |
Bacteria;Zika virus
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ln Vitro |
Dianemycin(Nangangmycin) is used to treat chicken coccidiosis and as a growth promoter in poultry. Dianemycin is effective against malaria strains that are resistant to drugs[1].
A strong inhibitor of Zika virus (ZIKV) entry in all tested cell types, including physiologically relevant primary cells, is Dianemycin (Nanchangmycin). All three ZIKV strains are effectively inhibited from infecting any of the three cell types by dienicimycin. Dianemycin exhibits low toxicity within the range of 0.1 to 0.4 μM, which corresponds to the IC50s for infection. Furthermore, Dianemycin inhibits DENV in all cell types[2]. |
References |
Molecular Formula |
C47H78O14
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Molecular Weight |
867.11
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Exact Mass |
866.54
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Elemental Analysis |
C, 65.10; H, 9.07; O, 25.83
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CAS # |
35865-33-9
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Related CAS # |
Nanchangmycin;65101-87-3
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Appearance |
Solid powder
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SMILES |
COC1CCC(OC1C)OC2CC(C3(CCC4(O3)CC(C(C(C(/C=C(C(C(CC(C(O)=O)C)C)=O)\C)C)O4)C)O)C)OC5(C2C)OC(C6OC(CO)(C(CC6C)C)O)CC5C
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InChi Key |
FELYAZAWTURXNF-JJIBRWJFSA-N
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InChi Code |
InChI=1S/C47H78O14/c1-24(40(50)25(2)18-28(5)43(51)52)17-26(3)41-31(8)34(49)22-45(59-41)16-15-44(11,61-45)38-21-36(56-39-14-13-35(54-12)33(10)55-39)32(9)47(58-38)30(7)20-37(57-47)42-27(4)19-29(6)46(53,23-48)60-42/h17,25-39,41-42,48-49,53H,13-16,18-23H2,1-12H3,(H,51,52)/b24-17+
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Chemical Name |
(E)-8-(9-hydroxy-2'-(6-hydroxy-6-(hydroxymethyl)-3,5-dimethyltetrahydro-2H-pyran-2-yl)-9'-((5-methoxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-2,4',8,10'-tetramethyl-1,1',6,6'-tetraoxa[2,7'-bispiro[4.5]decan]-7-yl)-2,4,6-trimethyl-5-oxonon-6-enoic acid
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Synonyms |
Dianemycin; BRN1676784; BRN-1676784; BRN 1676784; Nanchangmycin
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HS Tariff Code |
2934.99.9001
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Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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Solubility (In Vitro) |
DMSO : ~100 mg/mL (~115.33 mM)
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Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.58 mg/mL (2.98 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.8 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.58 mg/mL (2.98 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.8 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly.  (Please use freshly prepared in vivo formulations for optimal results.) |
Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
1 mM | 1.1533 mL | 5.7663 mL | 11.5326 mL | |
5 mM | 0.2307 mL | 1.1533 mL | 2.3065 mL | |
10 mM | 0.1153 mL | 0.5766 mL | 1.1533 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration: mg/mL;
Method for preparing DMSO stock solution: mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation::Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
Proposed pathway of nanchangmycin biosynthesis in S. [1].Chem Biol. 2008 May;15(5):449-58. td> |
Sequence comparison of the Type II thioesterases encoded by the nanchangmycin (NanE), monensin (MonCII), and nigericin (NigCII) biosynthetic gene clusters. [1].Chem Biol. 2008 May;15(5):449-58. td> |
Deletion of the nanG5 glycosyl transferase gene of S. [1].Chem Biol. 2008 May;15(5):449-58. td> |