| Size | Price | Stock | Qty |
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| 5mg |
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| 10mg |
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| Other Sizes |
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| ln Vitro |
Peanut beer is susceptible to the bactericidal effects of dictamine (MIC: 64 μg/mL)[1]. In the HaCaT inflammation model, dictamine (2 μg/mL, 24 hours) can lower ROS and mitochondrial ROS as well as the production of TNF-α and IL-1β. Dictamine (0-100 μM, 12 hours) can induce cell lysis, migration, and temporary expansion of HCT116 cells, as well as HIF-1α and Slug mRNA cell proliferation [3].
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| ln Vivo |
In the oxazolone-induced atopic dermatitis model, becamide (2 μg/mL, 200 μL, once day for 14 days) attenuates skin edema and the epidermis [2]. In the HCT116 xenograft model, becamide (50 and 100 mg/kg, lateral, three times weekly) suppresses tumor development [3]. When administered topically, becamide (1 and 5 mg/kg, 200 μL) can enhance 2,4-dinitrophenol
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| Cell Assay |
Western Blot Analysis[3]
Cell Types: HCT116 Cell Tested Concentrations: 0-100 μM Incubation Duration: 12 hrs (hours) Experimental Results: Inhibition of HIF-1α (synthesis but not degradation) and Slug protein accumulation under hypoxic conditions. |
| Animal Protocol |
Animal/Disease Models: HCT116 xenograft tumor model [3]
Doses: 50 and 100 mg/kg Route of Administration: po, 3 times a week. Experimental Results: Inhibit tumor growth. Reduce HIF-1α and Slug protein levels in tumor tissues. |
| Toxicity/Toxicokinetics |
Toxicity Summary
Dictamnine has been shown to be phototoxic to human cell lines (namely Jurkat T cells and HaCaT keratinocytes). Although it is less phototoxic than the structurally related furocoumarins 5-methoxypsoralen and 8-methoxypsoralen, "it may play a major role in the elicitation of phytophotodermatitis because of its abundance in plants of the Rutaceae family." (A15434) |
| References |
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| Additional Infomation |
Dictamnine is an oxacycle, an organonitrogen heterocyclic compound, an organic heterotricyclic compound and an alkaloid antibiotic.
Dictamnine has been reported in Melicope triphylla, Zanthoxylum simulans, and other organisms with data available. A furoquinoline alkaloid, dictamnine, is very common within the family Rutaceae. It is the main alkaloid in the roots of Dictamnus albus and responsible for the mutagenicity of the drug derived from crude extracts. Dictamnine was also reported to be a phototoxic and photomutagenic compound. It participates in the severe skin phototoxicity of the plant. |
| Molecular Formula |
C12H9NO2
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|---|---|
| Molecular Weight |
199.2
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| Exact Mass |
199.063
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| CAS # |
484-29-7
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| PubChem CID |
68085
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| Appearance |
White to yellow solid powder
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| Density |
1.3±0.1 g/cm3
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| Boiling Point |
343.2±22.0 °C at 760 mmHg
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| Melting Point |
133.5ºC
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| Flash Point |
161.4±22.3 °C
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| Vapour Pressure |
0.0±0.7 mmHg at 25°C
|
| Index of Refraction |
1.672
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| LogP |
2.94
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| Hydrogen Bond Donor Count |
0
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| Hydrogen Bond Acceptor Count |
3
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| Rotatable Bond Count |
1
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| Heavy Atom Count |
15
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| Complexity |
234
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| Defined Atom Stereocenter Count |
0
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| InChi Key |
WIONIXOBNMDJFJ-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C12H9NO2/c1-14-11-8-4-2-3-5-10(8)13-12-9(11)6-7-15-12/h2-7H,1H3
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| Chemical Name |
4-methoxyfuro[2,3-b]quinoline
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~50 mg/mL (~250.99 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (12.55 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (12.55 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.5 mg/mL (12.55 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 5.0201 mL | 25.1004 mL | 50.2008 mL | |
| 5 mM | 1.0040 mL | 5.0201 mL | 10.0402 mL | |
| 10 mM | 0.5020 mL | 2.5100 mL | 5.0201 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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