Size | Price | Stock | Qty |
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100mg |
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250mg |
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500mg |
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1g |
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2g |
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Other Sizes |
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Purity: ≥98%
Dienestrol is a non-steroidal synthetic estrogen that functions as an agonist of the estrogen receptor to treat symptoms associated with menopause and postmenopause. Stilbestrol and it share a structural relationship. It is used to treat menopausal and postmenopausal symptoms, usually as a cream. It is an agonist of the estrogen receptor. Part of how estrogens function is by promoting a clear, regular vaginal discharge and promoting the health of the vulva and urethra. Hormone use or application relieves vaginal dryness and soreness as well as vulva itching, redness, and soreness. Vaginal estrogens are used to treat vulvar atrophy, an inflammatory skin condition of the genitalia, atrophic vaginitis, and atrophic urethritis, an inflammatory condition of the urethra.
Molecular Formula |
C18H18O2
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Molecular Weight |
266.3343
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Exact Mass |
266.13
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Elemental Analysis |
C, 81.17; H, 6.81; O, 12.01
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CAS # |
84-17-3
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Related CAS # |
Dienestrol-d2;1346606-45-8
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Appearance |
White to off-white crystalline powder
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SMILES |
C/C=C(/C(=C/C)/C1=CC=C(C=C1)O)\C2=CC=C(C=C2)O
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InChi Key |
NFDFQCUYFHCNBW-SCGPFSFSSA-N
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InChi Code |
InChI=1S/C18H18O2/c1-3-17(13-5-9-15(19)10-6-13)18(4-2)14-7-11-16(20)12-8-14/h3-12,19-20H,1-2H3/b17-3+,18-4+
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Chemical Name |
4-[(2E,4E)-4-(4-hydroxyphenyl)hexa-2,4-dien-3-yl]phenol
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Synonyms |
Dehydrostilbestrol; Restrol; Sexadien; Dienoestrol
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HS Tariff Code |
2934.99.9001
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Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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Solubility (In Vitro) |
DMSO: ~155 mg/mL (~582 mM)
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Solubility (In Vivo) |
Solubility in Formulation 1: 2.08 mg/mL (7.81 mM) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), suspension solution; with sonication.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.08 mg/mL (7.81 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C,1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.08 mg/mL (7.81 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
1 mM | 3.7547 mL | 18.7737 mL | 37.5474 mL | |
5 mM | 0.7509 mL | 3.7547 mL | 7.5095 mL | |
10 mM | 0.3755 mL | 1.8774 mL | 3.7547 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration: mg/mL;
Method for preparing DMSO stock solution: mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation::Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.