Size | Price | Stock | Qty |
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10mg |
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25mg |
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50mg |
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100mg |
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250mg |
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500mg |
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Other Sizes |
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Purity: ≥98%
Diphemanil methylsulfate (NSC 41725; NSC-41725; Prantal; Talpran; Diphemanil mesylate) is a quaternary ammonium anticholinergic agent used for a variety of conditions such as pylorospasm, peptic ulcer, gastric hyperacidity, hypermotility in gastritis, and hyperhidrosis. It acts by binding to muscarinic acetycholine receptors (mAchR), thus decreasing secretory excretion of stomach acids as well as saliva and sweat.
ln Vitro |
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ln Vivo |
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Animal Protocol |
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References |
Eur J Clin Pharmacol.1992;42(6):689-91.
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Molecular Formula |
C20H24N.CH3O4S
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Molecular Weight |
389.51
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CAS # |
62-97-5
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Related CAS # |
15394-62-4;62-97-5 (methylsulfate);
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Appearance |
Typically exists as solids (or liquids in special cases) at room temperature
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SMILES |
[O-]S(=O)(OC)=O.C[N+]1(C)CC/C(CC1)=C(C2=CC=CC=C2)\C3=CC=CC=C3
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Chemical Name |
4-(diphenylmethylene)-1,1-dimethylpiperidin-1-ium methyl sulfate
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Synonyms |
NSC41725; Diphemanil Methylsulfate; NSC 41725; NSC-41725; Prantal; Talpran;
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HS Tariff Code |
2934.99.9001
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Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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Solubility (In Vitro) |
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Solubility (In Vivo) |
Solubility in Formulation 1: 50 mg/mL (128.37 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication.
 (Please use freshly prepared in vivo formulations for optimal results.) |
Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
1 mM | 2.5673 mL | 12.8366 mL | 25.6733 mL | |
5 mM | 0.5135 mL | 2.5673 mL | 5.1347 mL | |
10 mM | 0.2567 mL | 1.2837 mL | 2.5673 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration: mg/mL;
Method for preparing DMSO stock solution: mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation::Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.