| Size | Price | Stock | Qty |
|---|---|---|---|
| 1g |
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| Other Sizes |
|
| ln Vitro |
Methylguanidine (39-60 nM) has a Ki value of 40 nM and quantitatively inhibits N-(2-piperidinylethyl)4-iodobenzamide [2]. The xylguanidine (0-10 μM) σ1 and σ2 adsorption have Ki values of 69 and 21 nM, respectively [4], and IC50 values of 100 and 90 nM, respectively [3].
|
|---|---|
| ln Vivo |
Micturition thresholds and intervals during anesthesia are impacted by methylguanidine (IV; 1–5 mg/kg once) [1]. Intraventricular dose of 1 μg ditoluene raises the anesthesia urination interval and threshold, as well as prolongs the anesthesia urination interval [1].
|
| Animal Protocol |
Animal/Disease Models: Male Std-Wistar rats anesthetized with urethane [1]
Doses: 1-5 mg/kg Route of Administration: intravenous (iv) (iv)injection; pressure [1]. 1-5 mg/kg once Experimental Results: Dose-dependent prolongation of micturition interval and increase in threshold pressure. The micturition reflex and dribbling are eliminated at the 5 mg/kg dose. |
| References |
|
| Additional Infomation |
1,2-bis(2-methylphenyl)guanidine is a member of toluenes.
|
| Molecular Formula |
C15H17N3
|
|---|---|
| Molecular Weight |
239.3156
|
| Exact Mass |
239.142
|
| CAS # |
97-39-2
|
| Related CAS # |
41130-39-6 (hydrochloride)
|
| PubChem CID |
7333
|
| Appearance |
White to off-white solid powder
|
| Density |
1.1±0.1 g/cm3
|
| Boiling Point |
396.1±45.0 °C at 760 mmHg
|
| Melting Point |
176-178 °C(lit.)
|
| Flash Point |
193.3±28.7 °C
|
| Vapour Pressure |
0.0±0.9 mmHg at 25°C
|
| Index of Refraction |
1.585
|
| LogP |
3.77
|
| Hydrogen Bond Donor Count |
2
|
| Hydrogen Bond Acceptor Count |
1
|
| Rotatable Bond Count |
3
|
| Heavy Atom Count |
18
|
| Complexity |
288
|
| Defined Atom Stereocenter Count |
0
|
| InChi Key |
OPNUROKCUBTKLF-UHFFFAOYSA-N
|
| InChi Code |
InChI=1S/C15H17N3/c1-11-7-3-5-9-13(11)17-15(16)18-14-10-6-4-8-12(14)2/h3-10H,1-2H3,(H3,16,17,18)
|
| Chemical Name |
1,2-bis(2-methylphenyl)guanidine
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
DMSO : ~150 mg/mL (~626.78 mM)
|
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (10.45 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (10.45 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 4.1785 mL | 20.8925 mL | 41.7851 mL | |
| 5 mM | 0.8357 mL | 4.1785 mL | 8.3570 mL | |
| 10 mM | 0.4179 mL | 2.0893 mL | 4.1785 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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