| Size | Price | Stock | Qty |
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| 50mg |
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| 100mg |
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| 250mg |
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| 500mg |
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| 1g |
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| 2g |
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| Other Sizes |
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Purity: ≥98%
DMOG (also called dimethyloxaloylglycine) is a novel, potent and cell permeable antagonist of α-ketoglutarate cofactor and competitive inhibitor for HIF prolyl hydroxylase with neuro- and cardioprotective effects. It acts by stabilizing HIF-1α expression at normal oxygen tensions in cultured cells. DMOG ia able to provide neuroprotection after traumatic brain injury. DMOG can provide enhanced efficacy with reduced systemic exposure in a murine model of colitis. DMOG efficiently suppresses hydroxyproline synthesis in intact cells, but shows only weakly active in the microsomal system. DMOG reduces FGF-2-induced proliferation and cyclin A expression by inhibiting prolyl hydroxylase activity in HPASMC
| ln Vitro |
When applied to intact cells, DMOG effectively inhibits the formation of hydroxyproline; however, it is only sporadically active in the microsomal system[1]. DMOG inhibits prolyl hydroxylase activity in HPASMC, which decreases FGF-2-induced proliferation and cyclin A expression[3].
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| ln Vivo |
In mice with ischemic skeletal muscles, DMOG causes angiogenesis and inhibits endogenous HIF inactivation[2]. In hyperlipidemic rats, DMOG-induced up-regulation of hypoxia-inducible factor-1α amplifies the cardioprotective benefits of ischemic postconditioning[4].
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| Animal Protocol |
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| References |
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| Additional Infomation |
Dimethyloxalylglycine is a glycine derivative that is the diester obtained by formal condensation of the carboxy groups of N-oxalylglycine with two molecules of methanol. It has a role as a neuroprotective agent and an EC 1.14.11.29 (hypoxia-inducible factor-proline dioxygenase) inhibitor. It is a glycine derivative, a methyl ester and a secondary carboxamide. It is functionally related to a N-oxalylglycine.
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| Molecular Formula |
C6H9NO5
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| Molecular Weight |
175.14
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| Exact Mass |
175.048
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| CAS # |
89464-63-1
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| Related CAS # |
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| PubChem CID |
560326
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| Appearance |
White to off-white solid powder
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| Density |
1.2±0.1 g/cm3
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| Melting Point |
46-48ºC
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| Index of Refraction |
1.440
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| LogP |
-0.56
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| Hydrogen Bond Donor Count |
1
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| Hydrogen Bond Acceptor Count |
5
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| Rotatable Bond Count |
5
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| Heavy Atom Count |
12
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| Complexity |
200
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| Defined Atom Stereocenter Count |
0
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| InChi Key |
BNJOZDZCRHCODO-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C6H9NO5/c1-11-4(8)3-7-5(9)6(10)12-2/h3H2,1-2H3,(H,7,9)
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| Chemical Name |
methyl 2-[(2-methoxy-2-oxoethyl)amino]-2-oxoacetate
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| Synonyms |
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
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| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
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| Solubility (In Vivo) |
Solubility in Formulation 1: 150 mg/mL (856.46 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication.
(Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 5.7097 mL | 28.5486 mL | 57.0972 mL | |
| 5 mM | 1.1419 mL | 5.7097 mL | 11.4194 mL | |
| 10 mM | 0.5710 mL | 2.8549 mL | 5.7097 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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