Size | Price | Stock | Qty |
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50mg |
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100mg |
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250mg |
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500mg |
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1g |
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2g |
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Other Sizes |
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Purity: ≥98%
Domperidone (R 33812; R-33812; KW5338; KW-5338; Motilium; Domperidona) is an orally bioactive dopamine D2 receptor antagonist and an antiemetic medication used to relieve nausea and vomiting. It also functions as a galactagogue and a gastric prokinetic agent. Because it is more tolerable than metoclopramide, domperidone is a good substitute for it in the treatment of gastroparesis. In Madin-Darby bovine kidney (MDBK) cells, the D2R antagonist domeperidone inhibits Equilibrative NT1 (ENT1) activity more when bromocriptine is present than when it is not, and it has a lower IC50 value than both of these drugs.
Targets |
Dopamine D2 receptor
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ln Vitro |
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ln Vivo |
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Animal Protocol |
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References |
Molecular Formula |
C22H24CLN5O2
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Molecular Weight |
425.91
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Exact Mass |
425.16
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Elemental Analysis |
C, 62.04; H, 5.68; Cl, 8.32; N, 16.44; O, 7.51
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CAS # |
57808-66-9
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Related CAS # |
Domperidone monomaleate; 83898-65-1; Domperidone-d6; 1329614-18-7
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Appearance |
Solid powder
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SMILES |
C1CN(CCC1N2C3=C(C=C(C=C3)Cl)NC2=O)CCCN4C5=CC=CC=C5NC4=O
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InChi Key |
FGXWKSZFVQUSTL-UHFFFAOYSA-N
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InChi Code |
InChI=1S/C22H24ClN5O2/c23-15-6-7-20-18(14-15)25-22(30)28(20)16-8-12-26(13-9-16)10-3-11-27-19-5-2-1-4-17(19)24-21(27)29/h1-2,4-7,14,16H,3,8-13H2,(H,24,29)(H,25,30)
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Chemical Name |
6-chloro-3-[1-[3-(2-oxo-3H-benzimidazol-1-yl)propyl]piperidin-4-yl]-1H-benzimidazol-2-one
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Synonyms |
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HS Tariff Code |
2934.99.9001
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Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
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Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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Solubility (In Vitro) |
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Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.75 mg/mL (6.46 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 27.5 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.75 mg/mL (6.46 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 27.5 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C,1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.75 mg/mL (6.46 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
1 mM | 2.3479 mL | 11.7396 mL | 23.4791 mL | |
5 mM | 0.4696 mL | 2.3479 mL | 4.6958 mL | |
10 mM | 0.2348 mL | 1.1740 mL | 2.3479 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration: mg/mL;
Method for preparing DMSO stock solution: mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation::Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
NCT Number | Recruitment | interventions | Conditions | Sponsor/Collaborators | Start Date | Phases |
NCT06171087 | Recruiting | Drug: Domperidon Drug: Placebo |
Emotions | German Institute of Human Nutrition |
August 1, 2023 | Phase 4 |
NCT01696734 | Recruiting | Drug: Domperidone Other: Questionnaire Administration |
Dyspepsia Esophagitis Gastroparesis |
M.D. Anderson Cancer Center | October 23, 2012 | Phase 3 |
NCT04699591 | Recruiting | Drug: Domperidone | GERD Gastroparesis Gastroesophageal Reflux |
Children's Mercy Hospital Kansas City |
April 2013 | Not Applicable |
NCT03221855 | Completed | Drug: Placebo Drug: Domperidone |
Breastfeeding | Hospital de Clinicas de Porto Alegre |
March 2013 | Early Phase 1 |
NCT03617016 | Completed | Drug: Placebo Drug: Domperidone |
Dyspepsia | Xian-Janssen Pharmaceutical Ltd. |
August 27, 2018 | Phase 4 |
Mean ± SD plasma acetaminophen concentration determined during an acetaminophen absorption test in 2 groups of 6 horses that were administered domperidone paste (1.1 [A] or 5.0 mg [B] of domperidone/kg; circles) or placebo paste (rectangles) orally (2 treatments/horse) and subsequently received oral administration of acetaminophen (20 mg/kg). Am J Vet Res . 2013 Aug;74(8):1103-10. td> |
Effect of dopamine solution on isolated strips of longitudinal smooth muscle obtained from the midjejunum of 6 horses that were euthanized for reasons other than gastrointestinal or other systemic disease after the muscle strips were preincubated with domperidone solution (10−4M; circles) or vehicle solution (rectangles) for 20 minutes. Am J Vet Res . 2013 Aug;74(8):1103-10. td> |