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Description: E-4031 is a novel, potent and selective blocker of hERG K+ channels, which is also termed as a class III antiarrhythmic agent. It selectively blocks hERG potassium (K+) channels. E4031 inhibits the rapid delayed-rectifier K+ current (IKr) and reversibly prolongs action potential duration in guinea pig papillary muscle and isolated ventricular myocytes, without affecting Na+ or Ca2+ inward currents.
References: Br J Pharmacol. 2012 Jan;165(2):467-78.; Eur J Pharmacol. 2014 Oct 5;740:263-70.
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2
Purity ≥98%
COA
MSDS
APD90, BVR and example of APs in hESC-CM. Br J Pharmacol. 2012 Jan;165(2):467-78.