Size | Price | Stock | Qty |
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1mg |
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5mg |
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Other Sizes |
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ln Vitro |
In human cells, exaluren (ELX-02) disulfate (100–400 μg/mL) may detect nonsense mutations without causing harm [1].
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ln Vivo |
Exaluren (ELX-02) disulfate (10 and 30 mg/kg; subcutaneous dose; every two doses for a total of 8 doses) accumulates in tissues in a dose-dependent manner with no gender differences [1]. In India, Exaluren (ELX-02) disulfate is available as a single (single subcutaneous injection of 10 mg/kg with a dosage volume of 5 mL/kg) and repeat formulations (twice weekly with 10 mg/kg/dose , lasts for 21 days; 7 times in total) for quicker absorption. Exaluren (ELX-02) disulfate is rapidly removed from dormancy in a biphasic manner with a terminal half-life (T1/2) of 0.5 hours [1]. In CtnsY226 null Accumulation of cystine [1]
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Cell Assay |
Cytotoxicity assay[1]
Cell Types: Wild-type human proximal tubule cells (HK-2) Tested Concentrations: 0, 100 and 400 μg/mL Incubation Duration: 0, 24, 48 and 72 hrs (hours) Experimental Results: Wild-type human proximal tubule Cytotoxicity assay of cells (HK-2) demonstrated 400 μg/mL at 0, 24, 48 and 72 hrs (hours). |
Animal Protocol |
Animal/Disease Models: 29 CtnsY226X/Y226X mice, 5-7 months old [1]
Doses: 10 and 30 mg/kg Route of Administration: subcutaneous injection, dose volume 5 mL/kg, weekly Two times for 28 days. (8 doses total) Experimental Results: The highest levels were measured in the kidneys, followed by the spleen and liver, with lower levels in other tissues (lungs, heart, cochlea and brain). |
References |
[1]. Leubitz A, et al. Safety, Tolerability, and Pharmacokinetics of Single Ascending Doses of ELX-02, a Potential Treatment for Genetic Disorders Caused by Nonsense Mutations, in Healthy Volunteers. Clin Pharmacol Drug Dev. 2019 Jan 16.
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Molecular Formula |
C₁₉H₄₂N₄O₁₈S₂
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Molecular Weight |
678.68
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CAS # |
2244622-33-9
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Related CAS # |
Exaluren;1375073-93-0;Exaluren sulfate;1375073-94-1
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Appearance |
Typically exists as solids (or liquids in special cases) at room temperature
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SMILES |
S(=O)(=O)(O)O.O([C@@H]1[C@@H]([C@H]([C@@H]([C@@H]([C@@H](C)O)O1)O)O)N)[C@@H]1[C@H](C[C@H]([C@@H]([C@H]1O[C@H]1[C@@H]([C@@H]([C@@H]([C@H](C)N)O1)O)O)O)N)N
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HS Tariff Code |
2934.99.9001
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Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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Solubility (In Vitro) |
H2O : ~100 mg/mL (~147.34 mM)
DMSO :< 1 mg/mL |
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Solubility (In Vivo) |
Solubility in Formulation 1: 100 mg/mL (147.34 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication.
 (Please use freshly prepared in vivo formulations for optimal results.) |
Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
1 mM | 1.4734 mL | 7.3672 mL | 14.7345 mL | |
5 mM | 0.2947 mL | 1.4734 mL | 2.9469 mL | |
10 mM | 0.1473 mL | 0.7367 mL | 1.4734 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration: mg/mL;
Method for preparing DMSO stock solution: mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation::Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.