| Size | Price | Stock | Qty |
|---|---|---|---|
| 100mg |
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| Other Sizes |
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| ln Vitro |
IL-17 mRNA is strongly inhibited by Enilconodium (Enilconodium; 3, 10, 30 μM; lasting 6 hours)[1]. Imazalil (1, 3, 10, 30, 100 μM; during 24 hours) was only tested by RT-PCR in HepG2 cells that expressed mPXR [1].
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|---|---|
| ln Vivo |
In a dose-dependent way, imazalil (enniconazole; 25–100 mg/kg) intraperitoneally raises cardiac Cyp3a11 mRNA levels considerably [2]. In comparison to monotherapy, the number of Ki-67 positive nuclei and Mcm2 mRNA levels were considerably raised when Imazalil (75 mg/kg; i.p.; twice; one daily) was supplemented with TCPOBOP (3 mg/kg). Imazalil can hasten the growth of liver cancer cells that are induced by TCPOBOP therapy [2]. Male C57BL/6 mice are given imazalil (0.1, 0.5, 2.5 mg/kg; rural; for 15 weeks) which promotes oxidation of Manhattan and bile acid activity [3].
|
| Cell Assay |
RT-PCR[1]
Cell Types: EL4 cells Tested Concentrations: 3, 10, 30 μM Incubation Duration: 6 h Experimental Results: Dramatically suppressed IL-17 mRNAs. |
| Animal Protocol |
Animal/Disease Models: IMZ male C57BL/6N mice [2]
Doses: 25, 50, 75, 100 mg/kg Route of Administration: intraperitoneal (ip) injection; single dose Experimental Results: Dramatically increased liver Cyp3a11 mRNA levels in a dose-dependent manner. |
| References |
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| Additional Infomation |
Imazalil can cause cancer according to The Environmental Protection Agency (EPA).
1-[2-(allyloxy)-2-(2,4-dichlorophenyl)ethyl]imidazole is a member of the class of imidazoles in which the hydrogen at position 1 is replaced by a 2-(allyloxy)-2-(2,4-dichlorophenyl)ethyl group. It is a member of imidazoles, an ether and a dichlorobenzene. Enilconazole has been reported in Ganoderma lucidum with data available. Enilconazole (synonyms imazalil, chloramizole) is a fungicide widely used in agriculture, particularly in the growing of citrus fruits. Trade names include Freshgard, Fungaflor, and Nuzone. See also: Imazalil sulfate (annotation moved to). |
| Molecular Formula |
C14H14CL2N2O
|
|---|---|
| Molecular Weight |
297.17
|
| Exact Mass |
296.048
|
| CAS # |
35554-44-0
|
| Related CAS # |
33586-66-2 (mononitrate);58594-72-2 (unspecified sulfate)
|
| PubChem CID |
37175
|
| Appearance |
Light yellow to yellow solid powder
|
| Density |
1.348
|
| Boiling Point |
448.5±45.0 °C at 760 mmHg
|
| Melting Point |
52.7°C
|
| Flash Point |
225.1±28.7 °C
|
| Vapour Pressure |
0.0±1.0 mmHg at 25°C
|
| Index of Refraction |
1.573
|
| LogP |
3.58
|
| Hydrogen Bond Donor Count |
0
|
| Hydrogen Bond Acceptor Count |
2
|
| Rotatable Bond Count |
6
|
| Heavy Atom Count |
19
|
| Complexity |
291
|
| Defined Atom Stereocenter Count |
0
|
| InChi Key |
PZBPKYOVPCNPJY-UHFFFAOYSA-N
|
| InChi Code |
InChI=1S/C14H14Cl2N2O/c1-2-7-19-14(9-18-6-5-17-10-18)12-4-3-11(15)8-13(12)16/h2-6,8,10,14H,1,7,9H2
|
| Chemical Name |
1-[2-(2,4-dichlorophenyl)-2-prop-2-enoxyethyl]imidazole
|
| Synonyms |
1-(2-(2,4-Dichlorophenyl)-2-(2-propenyloxy)ethyl)-1H-imidazole; Enilconazole; Imazalil
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
DMSO : ≥ 100 mg/mL (~336.50 mM)
H2O : ~20 mg/mL (~67.30 mM) |
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (8.41 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (8.41 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.5 mg/mL (8.41 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. Solubility in Formulation 4: 1 mg/mL (3.36 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), suspension solution; with ultrasonication. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.3651 mL | 16.8254 mL | 33.6508 mL | |
| 5 mM | 0.6730 mL | 3.3651 mL | 6.7302 mL | |
| 10 mM | 0.3365 mL | 1.6825 mL | 3.3651 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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