| Size | Price | Stock | Qty |
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| 5mg |
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| 10mg |
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| 25mg |
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Enterostatin, human, mouse, rat is a novel and potent pentapeptide that can reduce the intake of fat. Enterostatin is a pentapeptide generated by trypic digestion of procolipase in the small intestine. Both peripheral and central administration of this peptide to rats has been shown to reduce food intake, this reduction being due to specific suppression of fat intake
| ln Vitro |
Enterostatin suppresses the insulin response in the perfused rat pancreas by 70% at 100 mM, 40% at 0.1 mM tolbutamide, and 70% at 5 mM arginine[1].
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|---|---|
| ln Vivo |
Enterostatin decreases body weight, body fat, and fat consumption over time. Enterostatin's various metabolic effects, such as decreased insulin secretion, increased sympathetic drive to brown adipose tissue, and stimulated adrenal corticosteroid secretion, may be involved in this response[2]. In a step-through type passive avoidance test in mice, enterostatin improves memory consolidation following central or oral treatment at a level of 10 nmol/mouse or 300 mg/kg, respectively[3]. Enterostatin at 38 nmol significantly reduces the amount of high-fat foods consumed; but, by 76 nmol, the inhibitory effect is no longer there. There is also a minor increase in food intake within the first hour following enterostatin injection[4].
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| References | |
| Additional Infomation |
APGPR Enterostatin is a peptide.
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| Molecular Formula |
C₂₁H₃₆N₈O₆
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|---|---|
| Molecular Weight |
496.56
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| Exact Mass |
496.276
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| CAS # |
117830-79-2
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| PubChem CID |
3082883
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| Appearance |
White to off-white solid powder
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| Density |
1.54g/cm3
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| Index of Refraction |
1.681
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| LogP |
-5
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| Hydrogen Bond Donor Count |
6
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| Hydrogen Bond Acceptor Count |
8
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| Rotatable Bond Count |
11
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| Heavy Atom Count |
35
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| Complexity |
846
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| Defined Atom Stereocenter Count |
4
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| SMILES |
C[C@@H](C(=O)N1CCC[C@H]1C(=O)NCC(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)N
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| InChi Key |
ITZMJCSORYKOSI-AJNGGQMLSA-N
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| InChi Code |
InChI=1S/C21H36N8O6/c1-12(22)19(33)29-10-4-6-14(29)17(31)26-11-16(30)28-9-3-7-15(28)18(32)27-13(20(34)35)5-2-8-25-21(23)24/h12-15H,2-11,22H2,1H3,(H,26,31)(H,27,32)(H,34,35)(H4,23,24,25)/t12-,13-,14-,15-/m0/s1
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| Chemical Name |
(2S)-2-[[(2S)-1-[2-[[(2S)-1-[(2S)-2-aminopropanoyl]pyrrolidine-2-carbonyl]amino]acetyl]pyrrolidine-2-carbonyl]amino]-5-(diaminomethylideneamino)pentanoic acid
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~125 mg/mL (~251.73 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.08 mg/mL (4.19 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. Solubility in Formulation 2: ≥ 2.08 mg/mL (4.19 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.0139 mL | 10.0693 mL | 20.1386 mL | |
| 5 mM | 0.4028 mL | 2.0139 mL | 4.0277 mL | |
| 10 mM | 0.2014 mL | 1.0069 mL | 2.0139 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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