| Size | Price | Stock | Qty |
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| 25g |
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| 50g |
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| 100g |
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| 200g |
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| Other Sizes |
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Erythrosine sodium (close form, CI-45430 CI45430; CI 45430) is a tetraiodofluorescein and a dye used as a fluorescent indicator in microscopy and for adsorption.
| ln Vitro |
The only concentrations of erythrosine B that differed substantially from the carrier cosmetic (p<0.05) were the two highest tested concentrations (50.0 and 70.0 μg/mL), when measuring tail shock and tail intensity, which indicate the degree of DNA damage. In comparison to the vehicle control group, the frequency of six micronuclei (MNi) increased across seven erythrosine B concentrations (0.2 to 70.0 μg/mL) [1].
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| References |
[1]. Chen W, et al. Establishing an experimental rat model of photodynamically-induced retinal vein occlusion using erythrosin B. Int J Ophthalmol. 2014 Apr 18;7(2):232-8.
[2]. Chequer FM, et al. Genotoxic and mutagenic effects of erythrosine B, a xanthene food dye, on HepG2 cells. Food Chem Toxicol. 2012 Oct;50(10):3447-51 |
| Molecular Formula |
C20H6I4NA2O5
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|---|---|
| Molecular Weight |
879.86
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| CAS # |
16423-68-0
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| Appearance |
Typically exists as solids (or liquids in special cases) at room temperature
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| SMILES |
IC1C(=C(C([H])=C2C=1OC1=C(C(=C(C([H])=C1C12C2=C([H])C([H])=C([H])C([H])=C2C(=O)O1)I)[O-])I)I)[O-].[Na+].[Na+]
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| Synonyms |
CI-45430 CI45430 CI 45430 Erythrosine sodium (close form)
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture and light. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
H2O : ~33.33 mg/mL (~37.88 mM)
DMSO : ~33.33 mg/mL (~37.88 mM) |
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (2.84 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (2.84 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: 33.33 mg/mL (37.88 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with ultrasonication. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.1365 mL | 5.6827 mL | 11.3654 mL | |
| 5 mM | 0.2273 mL | 1.1365 mL | 2.2731 mL | |
| 10 mM | 0.1137 mL | 0.5683 mL | 1.1365 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
Products are for research use only; We do not sell to patients
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