Size | Price | Stock | Qty |
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100mg |
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250mg |
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500mg |
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1g |
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Other Sizes |
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Purity: ≥98%
Estropipate (formerly piperazine estrone sulfate), a female sex hormone produced by the ovaries that functions as an agonist for the estrogen receptor and a type of estrogen. The body needs estrogen for a number of functions. Estropipate is used to prevent osteoporosis (bone loss) in menopausal women and to treat menopause symptoms like hot flashes and vaginal changes. It serves a variety of purposes. Menopause symptoms can be relieved by hormone replacement therapy, infertility treatments, conditions that cause female sexual characteristics to underdevelop, prostate cancer treatments, and osteoporosis prevention. The nuclear estrogen receptor, which is present in the breast, pituitary, hypothalamus, liver, and bone, is bound by escropipate as it diffuses across cell membranes. The activated complex binds to the DNA's estrogen response element, triggering the transcription of genes related to the development of secondary sex traits and the operation of the female reproductive system.
References |
Bagdade JD, Subbaiah PV. Effects of estropipate treatment on plasma lipids and
lipoprotein lipid composition in postmenopausal women. J Clin Endocrinol Metab.
1991 Feb;72(2):283-6. PubMed PMID: 1991799.
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Molecular Formula |
C22H32N2O5S
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Molecular Weight |
436.5649
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Exact Mass |
436.20
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Elemental Analysis |
C, 60.53; H, 7.39; N, 6.42; O, 18.32; S, 7.34
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CAS # |
7280-37-7
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Related CAS # |
7280-37-7
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Appearance |
Solid powder
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SMILES |
C[C@]12CC[C@H]3[C@H]([C@@H]1CCC2=O)CCC4=C3C=CC(=C4)OS(=O)(=O)O.C1CNCCN1
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InChi Key |
HZEQBCVBILBTEP-ZFINNJDLSA-N
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InChi Code |
InChI=1S/C18H22O5S.C4H10N2/c1-18-9-8-14-13-5-3-12(23-24(20,21)22)10-11(13)2-4-15(14)16(18)6-7-17(18)19;1-2-6-4-3-5-1/h3,5,10,14-16H,2,4,6-9H2,1H3,(H,20,21,22);5-6H,1-4H2/t14-,15-,16+,18+;/m1./s1
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Chemical Name |
[(8R,9S,13S,14S)-13-methyl-17-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-yl] hydrogen sulfate;piperazine
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Synonyms |
Estropipate; Piperazine estrone sulfate; Piperazine estronesulfate; Harmogen; Ogen
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HS Tariff Code |
2934.99.9001
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Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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Solubility (In Vitro) |
DMSO: 87~110 mg/mL (199.3~252 mM)
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Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.75 mg/mL (6.30 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 27.5 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.75 mg/mL (6.30 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 27.5 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C,1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.75 mg/mL (6.30 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
1 mM | 2.2906 mL | 11.4532 mL | 22.9064 mL | |
5 mM | 0.4581 mL | 2.2906 mL | 4.5813 mL | |
10 mM | 0.2291 mL | 1.1453 mL | 2.2906 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration: mg/mL;
Method for preparing DMSO stock solution: mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation::Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.