| Size | Price | Stock | Qty |
|---|---|---|---|
| 2mg |
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| 5mg |
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| 10mg |
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| 25mg |
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| Other Sizes |
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Etilevodopa HCl (TV-1203; Levodopa ethyl ester; L-Dopa ethyl ester; O-Ethyl-DOPA), the hydrochloride salt of Etilevodopa, is a dopaminergic agent used for the treatment for Parkinson's disease. It is an ethyl-ester prodrug of levodopa that has greater gastric solubility, passes quickly into the small intestine, is rapidly hydrolyzed to levodopa, and has a shortened time to maximum levodopa concentration.
| ln Vitro |
After traveling through the stomach unaltered, ativodopa (levodopa ethyl ester) hydrochloride enters the duodenum, where local esterase quickly hydrolyzes it into levodopa and ethanol, which is then quickly absorbed into the bloodstream as levodopa. Stream [1]. Azidovopa hydrochloride is more soluble in the stomach, enters the small intestine more quickly, and achieves the maximum levodopa concentration in less time when compared to regular levodopa [2].
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|---|---|
| References |
|
| Molecular Formula |
C11H16CLNO4
|
|---|---|
| Molecular Weight |
261.702
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| Exact Mass |
261.077
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| CAS # |
39740-30-2
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| Related CAS # |
Etilevodopa;37178-37-3
|
| PubChem CID |
12485237
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| Appearance |
Light yellow to yellow solid powder
|
| LogP |
2.033
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| Hydrogen Bond Donor Count |
4
|
| Hydrogen Bond Acceptor Count |
5
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| Rotatable Bond Count |
5
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| Heavy Atom Count |
17
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| Complexity |
234
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| Defined Atom Stereocenter Count |
1
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| SMILES |
CCOC(=O)[C@H](CC1=CC(=C(C=C1)O)O)N.Cl
|
| InChi Key |
CVQFXVIIFKVRCK-QRPNPIFTSA-N
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| InChi Code |
InChI=1S/C11H15NO4.ClH/c1-2-16-11(15)8(12)5-7-3-4-9(13)10(14)6-7;/h3-4,6,8,13-14H,2,5,12H2,1H3;1H/t8-;/m0./s1
|
| Chemical Name |
ethyl (2S)-2-amino-3-(3,4-dihydroxyphenyl)propanoate;hydrochloride
|
| Synonyms |
TV-1203 HClL-Dopa ethyl ester Levodopa ethyl ester TV1203 Etilevodopa
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: (1). This product requires protection from light (avoid light exposure) during transportation and storage. (2). Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
H2O : ~125 mg/mL (~477.65 mM)
|
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: 25 mg/mL (95.53 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication.
(Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.8212 mL | 19.1058 mL | 38.2117 mL | |
| 5 mM | 0.7642 mL | 3.8212 mL | 7.6423 mL | |
| 10 mM | 0.3821 mL | 1.9106 mL | 3.8212 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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